Examining bone health and vascular calcification in kidney transplant patients
A Prospective Observational Study to Investigate the Natural History of Bone Histomorphometry and Vascular Calcification in Dialysis-dependent Patients Before and After Renal Transplantation.
This study looks at how kidney transplants affect bone health and blood vessel hardening in patients with severe kidney disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven, Vlaams-Brabant) |
| Trial ID | NCT01886950 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the natural history of bone and mineral disease in patients with end-stage renal disease, specifically focusing on chronic kidney disease stage 5. It aims to understand the role of certain uremic retention molecules in the development of bone abnormalities and arterial calcification before and after kidney transplantation. The study will assess how renal transplantation influences bone and arterial metabolism in these patients, providing insights into the management of renal osteodystrophy and related complications.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who are eligible for renal transplantation.
Not a fit: Patients who have used bisphosphonates within the 6 months prior to study entry may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for bone and mineral disorders in kidney transplant patients.
How similar studies have performed: Other studies have shown success in understanding bone and mineral disorders in chronic kidney disease, but the specific focus on the role of uremic retention molecules in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * eligible for renal transplantation and \>18 years Exclusion Criteria: * use of biphosphonates within the 6 months before the study entry
Where this trial is running
Leuven, Vlaams-Brabant
- UZ Leuven Gasthuisberg — Leuven, Vlaams-Brabant, Belgium (Recruiting)
Study contacts
- Principal investigator: Pieter Evenepoel, MD,PhD — UZ Leuven
- Study coordinator: Pieter Evenepoel, MD, PhD
- Email: pieter.evenepoel@uzleuven.be
- Phone: 003216344591
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.