Examining blood vessel health in obese adults with insulin resistance using Vitamin C

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how obesity and insulin resistance contribute to hypertension and cardiovascular diseases by examining blood vessel health and nerve activity in affected adults. It specifically tests the effects of ascorbic acid (Vitamin C) on improving blood vessel function and lowering blood pressure. Participants will be monitored for changes in blood pressure as a primary outcome, with the goal of identifying mechanisms to reduce vascular dysfunction. The study aims to provide insights that could lead to targeted interventions for hypertension in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Obese: BMI \>30 m/kg2
2. Middle-aged: 35-65 years
3. Participants must be willing and able to discontinue taking any vitamin C or E supplements or omega-3 fatty acids beginning 2 weeks prior.
4. Able and willing to provide written informed consent

Exclusion Criteria:

1. Diabetes mellitus: fasting glucose \< 1267 mg/dL and/or HbA1c \< 6.5%
2. Currently taking a statin or antihypertension medication
3. Hyperlipidemia: Fasting triglycerides \< 250 mg/dL
4. Hypertension: \<130/80 mmHg
5. History of heart disease (e.g., myocardial infarction, stent)
6. History of vascular disease (e.g., bypass, stroke)

Where it's running

• University of Kansas Medical Center
  Kansas City, Kansas, United States Recruiting

Study contacts

• Principal investigator: Seth Holwerda, PhD — University of Kansas Medical Center
• Study coordinator: Seth Holwerda, PhD
• Email: sholwerda@kumc.edu
• Phone: 9729223230

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.