Examining blood vessel function in women after preeclampsia
Sensitivity of Angiotensin II Type II Receptors in Women Following Preeclampsia
EARLY_PHASE1 · University of Iowa · NCT05937841
This study is testing if a new approach can help women who had preeclampsia during pregnancy understand their heart and blood vessel health better compared to those who had healthy pregnancies.
Quick facts
| Phase | EARLY_PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | University of Iowa (other) |
| Locations | 1 site (Iowa City, Iowa) |
| Trial ID | NCT05937841 on ClinicalTrials.gov |
What this trial studies
This investigation focuses on understanding the long-term cardiovascular risks faced by women who experienced preeclampsia during pregnancy. It aims to explore the microvascular differences in these women by activating protective angiotensin receptors in the skin, comparing them to women who had healthy pregnancies. The study will involve women aged 18-45 who are between 12 weeks to 5 years postpartum, assessing the mechanisms behind impaired endothelial function and potential treatment strategies. By identifying these mechanisms, the research seeks to improve clinical management of cardiovascular disease risk in this population.
Who should consider this trial
Good fit: Ideal candidates are women aged 18-45 who are 12 weeks to 5 years postpartum, with a history of preeclampsia or a healthy pregnancy.
Not a fit: Patients with a history of hypertension, metabolic disease, or current tobacco use may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for managing cardiovascular disease risk in women who have had preeclampsia.
How similar studies have performed: While this approach is novel, previous studies have indicated that understanding the angiotensin system may provide insights into cardiovascular risks, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * women who had preeclampsia and women who did not have preeclampsia * 12 weeks to 5 years postpartum * 18-45 years old Exclusion Criteria: * history of hypertension or metabolic disease before pregnancy * history of gestational diabetes * skin diseases * current tobacco use * current antihypertensive medication * statin or other cholesterol-lowering medication * currently pregnant or planning to become pregnant * body mass index less than 18.5 kg/m2 * allergy to materials used during the experiment.(e.g. latex), * known allergy to study drugs
Where this trial is running
Iowa City, Iowa
- University of Iowa — Iowa City, Iowa, United States (RECRUITING)
Study contacts
- Principal investigator: Anna Reid-Stanhewicz, PhD — University of Iowa
- Study coordinator: Kelsey Schwartz
- Email: kelsey-schwartz@uiowa.edu
- Phone: 319-467-3096
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Preeclampsia Postpartum