Examining blood-derived vesicles in women with placenta previa and accreta spectrum
Shedding of Syncytiotrophoblast-derived Extracellular Vesicles is Increased in Placenta Previa and Accreta Spectrum: a Case-control Study.
NA · Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT06867874
This study is trying to see if the levels of certain tiny particles in the blood can help us understand placenta previa and placenta accreta in women compared to healthy pregnancies.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS (other) |
| Locations | 1 site (Roma) |
| Trial ID | NCT06867874 on ClinicalTrials.gov |
What this trial studies
This case-control study aims to quantify the levels of syncytiotrophoblast-derived extracellular vesicles (STBEVs) in the maternal blood of women diagnosed with placenta previa and placenta accreta spectrum. It compares these levels to those in healthy pregnant women with normal placentation. Additionally, the study seeks to characterize the multi-omics profiling of the STBEVs cargo, including proteins, genes, and transcripts, to better understand their role in these conditions.
Who should consider this trial
Good fit: Ideal candidates include pregnant women diagnosed with placenta previa and accreta spectrum, as well as healthy pregnant women over 18 years old.
Not a fit: Patients under 18 years, those with twin pregnancies, chronic infections, cancers, or who cannot provide written consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and therapeutic strategies for managing placenta previa and accreta spectrum.
How similar studies have performed: While the approach of analyzing extracellular vesicles is gaining traction, the specific focus on STBEVs in the context of placenta previa and accreta spectrum is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant women with diagnosis of placenta previa and accreta spectrum (cases) * Healthy pregnant women * \> 18 years Exclusion Criteria: * \< 18 years * Twin pregnancies * Chronic Infections * Cancers * Unable to give the written consent
Where this trial is running
Roma
- Fondazione Policlinico Universitario A.Gemelli IRCSS — Roma, Italy (RECRUITING)
Study contacts
- Principal investigator: Chiara Tersigni — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Study coordinator: Chiara Tersigni
- Email: chiara.tersigni@policlinicogemelli.it
- Phone: +39 3206557088
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Placenta Previa, Placenta Accreta Spectrum