Examining abdominal fluid characteristics in patients with severe diverticulitis
Study of Changes in Abdominal Fluid in Connection With Peritonitis. A Descriptive Study in Patients With Purulent or Fecal Peritonitis.
This study is trying to learn more about the fluid in the abdomen of patients with severe diverticulitis who need emergency surgery, by comparing them to others with milder diverticulitis and colorectal cancer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Sex | All |
| Sponsor | Sahlgrenska University Hospital Academic / other |
| Locations | 1 site (Gothenburg, Västra Götaland Region) |
| Trial ID | NCT04427891 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the characteristics of abdominal fluid in patients suffering from perforated diverticulitis with peritonitis, who are undergoing emergency surgery. It compares these patients to control groups, including those with mild diverticulitis and colorectal cancer. The study analyzes immune activity through immunoassays of proteins, gene expression in tissue samples, and bacterial diversity in fecal and mucosal samples. The goal is to understand the underlying inflammatory processes and microbiota changes associated with this severe condition.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with perforated diverticulitis requiring emergency surgery, as well as those with mild diverticulitis or colorectal cancer undergoing elective surgery.
Not a fit: Patients who do not require surgery or have withdrawn consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of perforated diverticulitis and lead to improved treatment strategies.
How similar studies have performed: While similar studies have explored aspects of diverticulitis, this specific focus on abdominal fluid characteristics in severe cases is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Signs of perforated diverticulitis with peritonitis and decision to perform emergency surgery (Group I) * Signs of acute diverticulitis and no decision of emergency surgery (Group II) * Patients with colorectal cancer planned for elective surgery (Group III) Exclusion Criteria: * No surgery performed (Group I and III) * Withdrawn consent (any group)
Where this trial is running
Gothenburg, Västra Götaland Region
- Sahlgrenska University Hospital/Östra — Gothenburg, Västra Götaland Region, Sweden (Recruiting)
Study contacts
- Principal investigator: Eva Haglind, MD,PhD — Sahlgrenska univesitetssjukhuset
- Study coordinator: Eva Haglind, MD, PhD
- Email: eva.haglind@vgregion.se
- Phone: +46705349088
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.