Evaluation of patients with gastrointestinal diseases

Evaluation of Patients With Gastrointestinal Disease

National Institutes of Health Clinical Center (CC) · NCT05041374

This study is collecting health information and samples from adults with gut problems to help improve understanding and treatment of these conditions in the future.

Quick facts

Study typeObservational
Enrollment4000 (estimated)
Ages18 Years to 120 Years
SexAll
SponsorNational Institutes of Health Clinical Center (CC) (nih)
Locations1 site (Bethesda, Maryland)
Trial IDNCT05041374 on ClinicalTrials.gov

What this trial studies

This study aims to collect clinical data and biological samples from adults with known or suspected gastrointestinal disorders who are receiving treatment at the NIH. Participants will undergo standard clinical care, including physical exams and medical record reviews, while their data and samples will be retained for future research on gastrointestinal diseases. The goal is to enhance understanding and treatment of these conditions through ongoing and future research projects.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with known or suspected gastrointestinal disorders requiring clinical screening or treatment.

Not a fit: Patients with significant medical illnesses that may interfere with evaluations or those without a referring physician may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved assessment and treatment options for patients with gastrointestinal diseases.

How similar studies have performed: Other studies focusing on the natural history and biological sampling of gastrointestinal diseases have shown promise, indicating that this approach is supported by prior research.

Eligibility criteria

Show full inclusion / exclusion criteria
* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Male or female, aged \>= 18 years of age
2. Known or suspected gastrointestinal disorders or requiring clinical screening, management and/or treatment and follow-up per current American Gastroenterological Association (AGA), American Society for Gastrointestinal Endoscopy (ASGE) or the American Association for the Study of Liver Disease (AASLD).

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. Significant medical illnesses that the investigators feel may interfere with potential evaluations.
2. Absence of a referring community physician who would be able to manage care outside of the NIH.
3. Any medical, psychiatric, or social conditions which, in the opinion of the investigators, would make participation in this protocol not in the best interest of the patient.
4. Inability to provide informed consent.

Where this trial is running

Bethesda, Maryland

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Lower GI Disease, Gastrointestinal Diseases, Digestive System Diseases, Small Bowel Disease, Upper GI Disease, Natural History

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.