Evaluation of allogenic dentin grafts for preserving alveolar ridge after tooth extraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the efficacy of allogenic dentin grafts, specifically demineralized dentin allografts (DDA) and whole tooth allografts (WTA), for alveolar ridge preservation following tooth extraction. The study aims to address the limitations of autogenous bone grafts, such as donor site morbidity and limited availability, by utilizing grafts from human-extracted teeth. Participants will be assessed for biocompatibility and effectiveness of these grafts, contributing to sustainable dental practices and enhancing future prosthetic rehabilitation. The trial is significant for advancing knowledge in dental and maxillofacial surgery.

Why it matters

Who can join: the full rules

Inclusion and Exclusion Criteria for Donors:

Inclusion Criteria:

* Students, interns, or residents willing to participate and provide informed consent.
* No history of systemic diseases such as diabetes, hepatitis, or immune disorders.
* Negative blood screening for HIV, HBV, and HCV.
* Non-smokers or individuals who have not smoked within the last six months.

Exclusion Criteria:

* History of systemic conditions affecting oral or overall health.
* Positive blood tests for communicable diseases.
* Active oral infections or untreated dental caries.
* Pregnant or lactating individuals.
* Individuals with a history of smoking or substance abuse within the last six months.

Inclusion and Exclusion Criteria for Recipients:

Inclusion Criteria:

* Patients aged 18-60 years, requiring extraction of at least three teeth for clinical or therapeutic reasons.
* Patients in good systemic health without conditions that impair bone healing.
* Willingness to provide informed consent and participate in follow-ups.

Exclusion Criteria:

* Systemic conditions such as diabetes, osteoporosis, or immunodeficiency that could impair bone regeneration.
* Active oral infections at extraction sites.
* History of radiation therapy to the head and neck region.
* Smoking or smoking history within the last six months.
* Use of medications affecting bone metabolism (e.g., bisphosphonates, steroids).
* Pregnancy or lactation. Additional Justification for Extraction: Teeth chosen for extraction must meet one or more criteria:
* Severe periodontal disease.
* Irreversible pulpitis or structural damage.
* Non-restorable condition impacting oral health or functionality.

Where it's running

• Jordan University Hospital
  Amman, Jordan Recruiting

Study contacts

• Study coordinator: Soukaina Ryalat, Prof
• Email: salryalat@yahoo.com
• Phone: 00962795484463

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  Recruiting Kafrelsheikh University · Kafr ash Shaykh · NCT07242313

• Biotivity A/C Plus Membrane for Alveolar Ridge Preservation after Tooth Extraction

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• Comparing new bone graft materials for preserving jawbone after tooth extraction

  This study is testing a new bone graft material to see if it can better preserve jawbone after tooth extractions compared to a standard option, helping people who need implants in the future.

  Recruiting Nova Southeastern University · Fort Lauderdale, Florida · NCT06275789

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.