Evaluation of allogenic dentin grafts for preserving alveolar ridge after tooth extraction

Clinical and Radiographic Evaluation of Allogenic Dentin Grafts for Alveolar Ridge Preservation: A Prospective Clinical Trial

This study is testing if using grafts from human teeth can help preserve the bone in the jaw after a tooth is taken out, making it easier for people to get dental implants later.

Quick facts

• Phase: PHASE1; PHASE2
• Study type: Interventional
• Enrollment: 10 (estimated)
• Ages: 18 Years to 60 Years
• Sex: All
• Sponsor: Jordan University Hospital (other)
• Drugs / interventions: radiation
• Locations: 1 site (Amman)
• Trial ID: NCT06827665 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the efficacy of allogenic dentin grafts, specifically demineralized dentin allografts (DDA) and whole tooth allografts (WTA), for alveolar ridge preservation following tooth extraction. The study aims to address the limitations of autogenous bone grafts, such as donor site morbidity and limited availability, by utilizing grafts from human-extracted teeth. Participants will be assessed for biocompatibility and effectiveness of these grafts, contributing to sustainable dental practices and enhancing future prosthetic rehabilitation. The trial is significant for advancing knowledge in dental and maxillofacial surgery.

Who should consider this trial

Good fit: Ideal candidates include patients aged 18-60 years requiring extraction of at least three teeth and in good systemic health.

Not a fit: Patients with systemic diseases affecting bone healing or those with active oral infections may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could provide a safer and more sustainable option for patients needing alveolar ridge preservation.

How similar studies have performed: While there is limited research on allogenic dentin grafts, the innovative approach may offer new insights compared to traditional grafting methods.

Eligibility criteria

Inclusion and Exclusion Criteria for Donors:

Inclusion Criteria:

* Students, interns, or residents willing to participate and provide informed consent.
* No history of systemic diseases such as diabetes, hepatitis, or immune disorders.
* Negative blood screening for HIV, HBV, and HCV.
* Non-smokers or individuals who have not smoked within the last six months.

Exclusion Criteria:

* History of systemic conditions affecting oral or overall health.
* Positive blood tests for communicable diseases.
* Active oral infections or untreated dental caries.
* Pregnant or lactating individuals.
* Individuals with a history of smoking or substance abuse within the last six months.

Inclusion and Exclusion Criteria for Recipients:

Inclusion Criteria:

* Patients aged 18-60 years, requiring extraction of at least three teeth for clinical or therapeutic reasons.
* Patients in good systemic health without conditions that impair bone healing.
* Willingness to provide informed consent and participate in follow-ups.

Exclusion Criteria:

* Systemic conditions such as diabetes, osteoporosis, or immunodeficiency that could impair bone regeneration.
* Active oral infections at extraction sites.
* History of radiation therapy to the head and neck region.
* Smoking or smoking history within the last six months.
* Use of medications affecting bone metabolism (e.g., bisphosphonates, steroids).
* Pregnancy or lactation. Additional Justification for Extraction: Teeth chosen for extraction must meet one or more criteria:
* Severe periodontal disease.
* Irreversible pulpitis or structural damage.
* Non-restorable condition impacting oral health or functionality.

Where this trial is running

Amman

• Jordan University Hospital — Amman, Jordan (RECRUITING)

Study contacts

• Study coordinator: Soukaina Ryalat, Prof

Conditions: Alveolar Ridge Preservation