Evaluation of a new dental desensitizer for treating tooth sensitivity
Clinical Evaluation of Polycation-based New Dental Desensitizer on Dentin Hypersensitivity
This study is testing a new dental desensitizer to see if it can help people with tooth sensitivity feel better compared to a standard treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Peking University Hospital of Stomatology Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT06378255 on ClinicalTrials.gov |
What this trial studies
This clinical evaluation focuses on the safety and efficacy of a new polycation-based dental desensitizer for patients suffering from dentin hypersensitivity. The study involves 40 participants who will be randomly assigned to receive either the new desensitizer or a standard desensitizer (GLUMA) in a split-mouth design. Dentin sensitivity will be assessed through Visual Analog Scale (VAS) scores at multiple time points, and safety will be monitored for any adverse events. The primary goal is to determine the effectiveness of the new treatment in alleviating sensitivity symptoms over time.
Who should consider this trial
Good fit: Ideal candidates are individuals with dentin hypersensitivity and a VAS score of 4 or higher, with healthy pulp viability.
Not a fit: Patients with dental caries, large fillings, or those who have recently undergone dental treatments may not benefit from this study.
Why it matters
Potential benefit: If successful, this new desensitizer could provide longer-lasting relief from dentin hypersensitivity for patients.
How similar studies have performed: Previous studies have shown varying degrees of success with dental desensitizers, but this specific approach using a polycation-based formulation is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Dentin Hypersensitivity, with Vas score≥4 points and the normal pulp viability * dentin-sensitive tooth in at least 2 different quadrants of the mouth (neck enamel dentin exposure or maxillofacial abrasion within the middle layer of dentin). * in good overall health * participants informed consent. Exclusion Criteria: * gastroesophageal reflux * Dental caries, wedge defects, crowns or large fillings. * Received dentin sensitivity desensitization treatment or used desensitization mouthwash within 1 month. * Received systematic periodontal therapy or periodontal surgery within 3 months, ongoing orthodontic treatment, and medical treatment, including long-term use of anti-inflammatory, analgesic, and psychotropic medications. * Pregnancy or breastfeeding. * Participated in other clinical trials in the past 3 months.
Where this trial is running
Beijing, Beijing
- Peking University School and Hospital of Stomatology — Beijing, Beijing, China (Recruiting)
Study contacts
- Study coordinator: Qianqian Wang
- Email: wangqian0213@163.com
- Phone: +86-10-62173403
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.