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Evaluating YL205 for patients with advanced solid tumors

A Multi-center, Open-label, Phase I/II Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of YL205 in Patients With Advanced Solid Tumors

Phase1; Phase2 Interventional MediLink Therapeutics (Suzhou) Co., Ltd. · NCT06459973

This study is testing a new treatment called YL205 to see if it helps people with advanced solid tumors, like certain types of ovarian and lung cancer, feel better and manage their disease.

Quick facts

PhasePhase1; Phase2
Study typeInterventional
Enrollment252 (estimated)
Ages18 Years and up
SexAll
SponsorMediLink Therapeutics (Suzhou) Co., Ltd. Industry-sponsored
Drugs / interventionsradiation
Locations43 sites (Denver, Colorado and 42 other locations)
Trial IDNCT06459973 on ClinicalTrials.gov

What this trial studies

This is a multicenter, open-label clinical study assessing the safety, tolerability, pharmacokinetics, and preliminary efficacy of YL205 in patients with advanced solid tumors. The study will involve intravenous infusion of YL205 and will focus on patients with specific types of cancer, including ovarian cancer, non-squamous non-small cell lung cancer, renal cell carcinoma, and endometrial cancer. Participants will be monitored for their response to the treatment and any side effects experienced during the study.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with specific advanced solid tumors that overexpress Napi2b.

Not a fit: Patients with tumors that do not overexpress Napi2b or those with other unrelated advanced cancers may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with advanced solid tumors.

How similar studies have performed: While this approach is being explored in this specific context, similar studies targeting advanced solid tumors have shown promise in the past.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* 1\) Subjects who are informed of relevant information of the study prior to initiation of the study and voluntarily sign and date on the informed consent form (ICF).

  2\) Age ≥18 years. 3) Be willing to follow and be able to complete all the study procedures. 4) Body mass index (BMI) within the range of 18 to 32 kg/m2, and body weight ≥45kg for female subjects.

  5） Patients with histologically or cytologically confirmed locally advanced or metastatic ovarian cancer (OC), non-squamous non-small cell lung cancer (NSQ NSCLC), renal cell carcinoma (RCC), endometrial cancer (EC), or other Napi2b-overexpressing tumors。 6) Patients with positive Napi2b test results at the central laboratory. 9) At least one radiologically evaluable lesion for subjects in Part 1; At least one measurable extracranial lesion (non-radiation fields) for subjects in Part 2 and Part 3.

  10\) Expected survival ≥3 months. 11) Female subjects of childbearing potential must agree to take effective contraceptive measures and must not undergo egg donation or egg retrieval for their own use from screening throughout the study period and for at least 6 months after the last dose of the investigational drug. Male subjects must agree to take effective contraceptive measures and must not undergo sperm cryopreservation or sperm donation from screening throughout the study period and for at least 6 months after the last dose of the investigational drug.

  12\) subjects must provide tumor samples. 13) Subjects who are capable of and willing to comply with the visits and procedures stipulated in the study protocol.

Exclusion Criteria:

* 1\) Subjects with a treatment history with drugs targeting Napi2b. 2) Subjects with a history of intolerance to topoisomerase I inhibitors or ADC therapy.

  3\) Subjects who are participating in another clinical study, with the exception an of observational (non-interventional) clinical study or the follow-up period of an interventional study.

  4\) Subjects with an insufficient washout period from the previous anti-tumor therapy to the first dose.

  5\) Subjects who received radiotherapy, including palliative stereotactic radiotherapy on the abdomen, within 4 weeks prior to the first dose.

  6\) Subjects who received major surgery within 4 weeks prior to the first dose or those who plan to receive major surgery during the study.

  7\) Subjects who received allogeneic bone marrow transplantation or solid organ transplantation.

  8\) Subjects who received systemic steroids or other immunosuppressive treatment within 2 weeks prior to the first dose of the investigational drug.

  9\) Subjects who received any live vaccine within 4 weeks prior to the first dose or those who plan to receive live vaccines during the study.

  10\) Subjects with a medical history of leptomeningeal carcinoma or cancerous meningitis.

  11\) Subjects with brain metastasis or spinal cord compression. 12) Subjects with uncontrolled or clinically significant cardiovascular and cerebrovascular diseases.

  13\) Subjects who were diagnosed with Gilbert's syndrome. 14) Subjects with significantly symptomatic or unstable effusion in the third space requiring repeated drainage.

  15\) Subjects with medical history of gastrointestinal perforation and/or fistula within 6 months prior to the first dose, or active gastric ulcers, duodenal ulcer, colitis ulcerative, or other gastrointestinal disorders that may cause hemorrhage or perforation in the opinion of the investigator.

  16\) Subjects with serious infection (Grade ≥3 as per NCI CTCAE v5.0) prior to the first dose.

  17\) Subjects with human immunodeficiency virus (HIV), active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection; subjects with positive syphilis antibody and a positive titer result.

  18\) Subjects with unresolved toxicity caused by previous anti-tumor therapy. 20) Subjects with a history of serious allergic reactions to drugs, inactive ingredients in drug products, or other monoclonal antibodies.

  21\) Female subjects who are pregnant as confirmed by a pregnancy test within 3 days prior to the first dose, or lactating women.

  22\) Subjects who have any diseases, medical conditions, organ system dysfunction, or social conditions.

  23\) Subjects with multiple primary malignancies within 5 years prior to the signing of the ICF, except for fully resected non-melanoma skin cancer, radically treated carcinoma in situ, or other radically treated solid tumors.

Where this trial is running

Denver, Colorado and 42 other locations

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Advanced Solid Tumors
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.