Evaluating vision and health in patients with congenital lens dislocation
Official title: Follow up Study on Visual Prognosis and Complications of Ectopia Lentis Lens
Run by Zhongshan Ophthalmic Center, Sun Yat-sen University · NCT05654025 · Data updated 2026-11-12
This study looks at how congenital lens dislocation affects vision and mental health in patients, while also checking for genetic links and changes after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 3 Years and up |
| Sex | All |
| Enrollment | 604 (estimated) |
| Sponsor | Zhongshan Ophthalmic Center, Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | December 5, 2022 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | August 7, 2024 |
| Trial ID | NCT05654025 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals diagnosed with congenital lens dislocation who are aged 3 years or older.
✕Probably not a fit
Patients with a history of ophthalmic trauma, other eye diseases, or those unable to cooperate in examinations may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational cohort study focuses on patients with congenital ectopia lentis, aiming to assess their vision-related quality of life and mental health status. The study will also investigate the relationship between genetic factors and clinical outcomes, as well as analyze the metabolic profiles in the aqueous humor of these patients. Additionally, it will monitor changes in ocular biological parameters and complications following surgery in a Chinese population. The research is conducted at a single center, emphasizing the need for systematic evaluation of this rare condition.
Why it matters
Potential benefit: If successful, this study could enhance understanding of congenital ectopia lentis and improve patient care and outcomes.
How similar studies have gone: While there may be limited studies specifically on congenital ectopia lentis, similar observational studies in ophthalmology have shown promising results in understanding patient outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed with congenital lens dislocation and age ≥ 3 years old. * Agree to participate in this study with written informed consent from patients or legal guardians. Exclusion Criteria: * History of ophthalmic trauma or other ophthalmic surgeries. * Combined with other ophthalmic diseases such as primary glaucoma, uveitis and corneal disease. * Patients who could not cooperate in the examinations.
Where it's running
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Guangdong Provincial Clinical Research Center for Ocular Diseases, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Danying Zheng — Guangdong Provincial Clinical Research Center for Ocular Diseases
- Study coordinator: Dangying Zheng, M.D
- Email: zhengdyy@163.com
- Phone: 020-87330478
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Visual and perceptual training to improve sight after congenital ectopia lentis surgery in children
We will try a web-based visual and perceptual training program to see if it improves vision, stereoacuity, quality of life, and treatment adherence in children after surgery for congenital ectopia lentis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.