Evaluating vessel imaging for coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the diagnostic accuracy of optical coherence tomography (OCT) in evaluating plaque morphology and its correlation with vessel fractional flow reserve (vFFR) in patients with chronic coronary syndrome and intermediate grade coronary stenosis. It will analyze morphometric indices such as minimal lumen area and plaque type, including thin cap fibroatheroma. The study will also explore how factors like age, sex, diabetes, and renal dysfunction influence the relationship between vFFR and these morphometric parameters. Participants will undergo OCT and angiography to gather data for this analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years or older
* Chronic coronary syndrome defined as presence of chest pain ranked 2-3 in the Canadian Cardiovascular Society classification or positive ischemia test (exercise test, single photon emission tomography (SPECT)
* Intermediate grade coronary stenosis of 40-80% assessed visually in coronary angiography and OCT examination The patient is willing to participate in the study and has provided a written informed consent

Exclusion Criteria:

* Acute coronary syndrome
* Proximal left main lesion
* Ostial right coronary artery lesion
* Bypass of the assessed vessel
* Contraindications for adenosine administration
* Hemodynamic instability
* Heart insufficiency in New York Heart Association (NYHA) class IV scale
* Acute renal insufficiency
* Pregnancy

Where it's running

• 1st Department and Clinic of Cardiology, Medical University of Warsaw
  Warsaw, Mazowieckie Voivodenship, Poland Recruiting

Study contacts

• Study coordinator: Mariusz Tomaniak, MD, PhD, Assoc. Prof.
• Email: mariusz.tomaniak@wum.edu.pl
• Phone: 0048225991958

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.