Evaluating urinary biomarkers in spina bifida patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the potential of urinary biomarkers, specifically TIMP-2 and MMP-2, to predict the risk of upper urinary tract damage in patients with spina bifida. Participants will have their biomarkers measured during routine urodynamic assessments, which are part of their regular follow-up care. The study aims to correlate these biomarkers with the Galloway score, a measure of kidney health, to enhance monitoring and management of renal function in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Spina patients consulted as part of the multidisciplinary consultation of the spina bifida rare disease reference centre;
* Written consent to participate in the research.
* Compulsory membership of a social security scheme

Exclusion Criteria:

* Patients with a non-continuous trans ileal urinary diversion ;
* Patients with enterocystoplasty;
* Untreated bacteriuria at the time of urodynamic assessment and urine sample collection;
* History of urinary tract tumour;
* History of histologically proven interstitial cystitis;
* Persons under legal protection (safeguard of justice, curatorship, guardianship);
* Persons deprived of their liberty.
* Women claiming to be pregnant

Where it's running

• Rennes University Hospital
  Rennes, CHU de Rennes, France Recruiting

Study contacts

• Study coordinator: Loïc Jacob
• Email: loic.jacob@chu-rennes.fr
• Phone: 0299282555

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.