Evaluating ultrasound for diagnosing Dupuytren's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of ultrasound as a diagnostic tool for Dupuytren's disease (DD), a condition that affects hand function. Currently, diagnosis relies heavily on clinical evaluations and range of motion measurements, which may not provide comprehensive insights. The study aims to assess various ultrasound parameters that could serve as prognostic biomarkers for DD. By exploring this non-invasive and radiation-free method, the research seeks to enhance evidence-based decision-making in treatment options for patients with DD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures
2. Clinical diagnosis of DD and a Tubiana staging not exceeding stage II, TPED does not exceed 90°; this is chosen because to great of a contracture will pose problems with taking the US measurement.
3. In the clinical assessment the subject has rather soft DD nodules, more firm nodules are more fibrotic and are less likely to contain blood vessels. This will be confirmed by a hand surgeon at the screening phase.
4. Participant has self reported rapid progression. In the anamnesis the subject reports one of the following: The DD lesion has changed in degree of contracture/nodule size recently; the patient is worried about the function of the involved fingers/hand due to recent progression; the patient is new to DD or has just started experiencing greater discomfort due to a previous existing nodule.
5. Participant agrees to not undergo any form of surgical treatment for DD during the duration of their participation, being 6 months.
6. Participant agrees to return to the clinic after 6 months voluntarily for follow-up measurements.

Exclusion Criteria:

1. Participant has any other disorder or pathology of the hand/fingers that could affect the quality of US measurements. This list is exhaustive: trigger finger, fracture, hematoma, tenosynovitis, tendon ruptures, scleroderma, fibromatosis, inflammatory conditions, rheumatoid arthritis, osteoarthritis.
2. Participant has received prior treatment for Dupuytren's disease (needle fasciotomy, (micro)fasciectomy) in the hand under investigation.
3. Participant's affected finger exceeds a TPED over 90° (= Tubiana stage III) (this will affect the value of any US images taken)
4. Participant undergoes treatment for DD during the course of their participation in this study: exhaustive list: fasciectomy/fasciotomy/stretching braces/collagenase injections

Where it's running

• Universitaire Ziekenhuizen KU Leuven
  Leuven, Vlaams-Brabant, Belgium Recruiting

Study contacts

• Principal investigator: Ilse Degreef, Prof. Dr. — Universitaire Ziekenhuizen KU Leuven
• Study coordinator: Ilse Degreef, Prof. Dr.
• Email: ilse.degreef@uzleuven.be
• Phone: +32 16 33 88 43

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Treatment for early Dupuytren's disease using vitamin E cream

  This study is testing if using vitamin E cream can help people with early Dupuytren's disease stop their fingers from getting worse.

  Recruiting Phase 2 Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06321991

• Investigating the role of micronerves in Dupuytren's disease and their impact on recurrence

  This study looks at whether tiny nerve bundles in the hand affect how often Dupuytren's disease comes back after surgery in people with this condition.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06142929

• Treatment options for Dupuytren's contracture

  This study is testing whether adding a corticosteroid injection to a needle treatment helps people with Dupuytren's contracture move their fingers better.

  Recruiting Phase 4 Regionshospitalet Silkeborg · Silkeborg · NCT05440240

• Evaluating night splinting after needle fasciotomy for Dupuytren's contracture

  This study is testing if wearing a night splint after a needle procedure for Dupuytren's contracture can help prevent the condition from coming back compared to just physical therapy alone.

  Recruiting at 3 sites Uppsala University · Falun, Dalarna County and 2 other locations · NCT05300893

• Surgery with fat grafting for Dupuytren's disease recurrence

  This study is testing whether adding fat grafting to standard surgery for Dupuytren's disease can help prevent the condition from coming back.

  Recruiting at 2 sites Elsan · Pessac and 1 other locations · NCT05067764

• Evaluating post-surgery radiation treatment for Dupuytren's disease

  This study is testing whether adding radiation treatment after surgery for Dupuytren's disease can help improve hand function and reduce symptoms for patients.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04122313

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.