Evaluating treatments for elderly patients with lung cancer
Official title: PROspective Master-protocol for Evaluation of Systemic THErapeutics in Elderly
Run by Groupe Francais De Pneumo-Cancerologie · NCT06646471 · Data updated 2026-11-12
This study is trying to see how well different treatments work for older adults with lung cancer and how these treatments affect their quality of life.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 70 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Groupe Francais De Pneumo-Cancerologie Academic / other |
| Locations | 41 sites (Aix-en-Provence and 40 other locations) |
| Status | Recruiting |
| Started | September 26, 2024 |
| Main results expected | August 31, 2026 |
| Study ends | August 31, 2028 |
| Registry record updated | April 29, 2026 |
| Trial ID | NCT06646471 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 70 and older with non-small-cell lung cancer who have not previously received systemic treatment.
✕Probably not a fit
Patients who have already been treated with systemic therapy for lung cancer or those under guardianship will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to collect real-life data on patients aged 70 and older who are receiving first-line treatment for non-small-cell lung cancer. It will characterize participants based on geriatric, biological, and cancer-related factors, while also documenting treatment modalities and their efficacy, safety, and impact on quality of life. Participants will be monitored according to standard clinical practices, with regular check-ups and assessments to evaluate their treatment outcomes. Additionally, specific sub-cohorts will be formed to explore uniform treatment strategies.
Why it matters
Potential benefit: If successful, this study could improve treatment strategies and outcomes for elderly patients with lung cancer.
How similar studies have gone: Other studies focusing on elderly cancer patients have shown promising results, indicating that this approach is both relevant and potentially beneficial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient ≥70 years * Non-small-cell lung cancer for which the multidisciplinary consultation required systemic treatment regardless of Tumor-Node-Metastasis (TNM) stage * Patient naïve to systemic anticancer treatment for bronchial neoplasia * Patient covered by social security * Patient eligible for systemic treatment * Systemic treatment with marketing authorization in the indication, available in routine care early access or compassionate access. * Patient able to understand the protocol * Patient not opposed to the collection of data concerning him/her * Signature of study consent form. Exclusion Criteria: * Patients under guardians or curators * Patient not under the care of the investigating center and not monitored by the investigating center * Patient already treated with systemic therapy for NSCLC
Where it's running
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CH du Pays d Aix
Aix-en-Provence, France Recruiting -
Hôpital Henri Duffaut
Avignon, France Recruiting -
Institut du Cancer d'Avignon
Avignon, France Recruiting -
Oncologie Thoracique Hôpital Morvan
Brest, France Recruiting -
CH Métropole-Savoie
Chambéry, France Recruiting -
Centre Hospitalier du Cotentin
Cherbourg, France Recruiting
Show 35 more locations
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Pneumologie Hospices Civils de Colmar
Colmar, France Recruiting -
Pneumologie CHI Creteil
Créteil, France Recruiting -
CH Elbeuf
Elbeuf, France Recruiting -
CHD Les Oudairies
La Roche-sur-Yon, France Recruiting -
CH La Rochelle
La Rochelle, France Recruiting -
Hôpital A. Mignot
Le Chesnay, France Recruiting -
Hôpital Robert Boulin
Libourne, France Recruiting -
CHU Dupuytren
Limoges, France Recruiting -
Hôpital de la Vallée - Service Pneumologie
Longjumeau, France Recruiting -
Centre Léon Bérard
Lyon, France Recruiting -
Hôpital Européen de Marseille
Marseille, France Recruiting -
Oncologie Thoracique Hôpital Nord
Marseille, France Recruiting -
GHEF Site de Meaux
Meaux, France Recruiting -
Centre d Oncologie de Gentilly
Nancy, France Recruiting -
Pneumologie CHR
Orléans, France Recruiting -
CH Annecy Genevois
Pringy, France Recruiting -
Pneumologie CHI Quimper
Quimper, France Recruiting -
CHU Hôpital Ponchailloux
Rennes, France Recruiting -
Pneumologie CHU Felix Guyon
Saint-Denis, France Recruiting -
Pneumologie CHU St Etienne
Saint-Etienne, France Recruiting -
Clinique Mutualiste
Saint-Nazaire, France Recruiting -
CHU de la Réunion
Saint-Pierre, France Recruiting -
CLCC Paul Strauss
Strasbourg, France Recruiting -
Hôpital d'Instruction des Armées Saint-Anne
Toulon, France Recruiting -
CHITS Toulon Sainte Musse
Toulon, France Recruiting -
Oncologie CHBA
Vannes, France Recruiting -
Hôpital Nord OUest
Villefranche-sur-Saône, France Recruiting -
CH Bastia
Bastia, France Not yet recruiting -
Pneumologie Centre François Baclesse
Caen, France Not yet recruiting -
CHU Hôpital Montpied
Clermont-Ferrand, France Not yet recruiting -
Polyclinique de Blois
La Chaussée-Saint-Victor, France Not yet recruiting -
Pneumologie Hôpital Cochin
Paris, France Not yet recruiting -
Pneumologie Hôpital Tenon
Paris, France Not yet recruiting -
Cantre Catalan d Oncologie
Perpignan, France Not yet recruiting -
Pneumologie Hôpital Charles Nicolle
Rouen, France Not yet recruiting
Study contacts
- Study coordinator: Romain CORRE, Medical Doctor
- Email: romain.corre@ch-cornouaille.fr
- Phone: +330298526404
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.