Clinical trial Recruiting at 33 sites Phase 4 Interventional Ages 70 and up

Evaluating treatments for elderly patients with lung cancer

Official title: PROspective Master-protocol for Evaluation of Systemic THErapeutics in Elderly

Run by Groupe Francais De Pneumo-Cancerologie · NCT06646471 · Data updated 2026-11-12

This study is trying to see how well different treatments work for older adults with lung cancer and how these treatments affect their quality of life.

More Non-Small Cell Lung Cancer trials

Quick facts

PhasePhase 4
Study typeInterventional
Ages70 Years and up
SexAll
Enrollment500 (estimated)
SponsorGroupe Francais De Pneumo-Cancerologie
Academic / other
Locations41 sites (Aix-en-Provence and 40 other locations)
StatusRecruiting
StartedSeptember 26, 2024
Main results expectedAugust 31, 2026
Study endsAugust 31, 2028
Registry record updatedApril 29, 2026
Trial IDNCT06646471 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients aged 70 and older with non-small-cell lung cancer who have not previously received systemic treatment.

Probably not a fit

Patients who have already been treated with systemic therapy for lung cancer or those under guardianship will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to collect real-life data on patients aged 70 and older who are receiving first-line treatment for non-small-cell lung cancer. It will characterize participants based on geriatric, biological, and cancer-related factors, while also documenting treatment modalities and their efficacy, safety, and impact on quality of life. Participants will be monitored according to standard clinical practices, with regular check-ups and assessments to evaluate their treatment outcomes. Additionally, specific sub-cohorts will be formed to explore uniform treatment strategies.

Why it matters

Potential benefit: If successful, this study could improve treatment strategies and outcomes for elderly patients with lung cancer.

How similar studies have gone: Other studies focusing on elderly cancer patients have shown promising results, indicating that this approach is both relevant and potentially beneficial.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient ≥70 years
* Non-small-cell lung cancer for which the multidisciplinary consultation required systemic treatment regardless of Tumor-Node-Metastasis (TNM) stage
* Patient naïve to systemic anticancer treatment for bronchial neoplasia
* Patient covered by social security
* Patient eligible for systemic treatment
* Systemic treatment with marketing authorization in the indication, available in routine care early access or compassionate access.
* Patient able to understand the protocol
* Patient not opposed to the collection of data concerning him/her
* Signature of study consent form.

Exclusion Criteria:

* Patients under guardians or curators
* Patient not under the care of the investigating center and not monitored by the investigating center
* Patient already treated with systemic therapy for NSCLC

Where it's running

  • CH du Pays d Aix
    Aix-en-Provence, France
    Recruiting
  • Hôpital Henri Duffaut
    Avignon, France
    Recruiting
  • Institut du Cancer d'Avignon
    Avignon, France
    Recruiting
  • Oncologie Thoracique Hôpital Morvan
    Brest, France
    Recruiting
  • CH Métropole-Savoie
    Chambéry, France
    Recruiting
  • Centre Hospitalier du Cotentin
    Cherbourg, France
    Recruiting
Show 35 more locations
  • Pneumologie Hospices Civils de Colmar
    Colmar, France
    Recruiting
  • Pneumologie CHI Creteil
    Créteil, France
    Recruiting
  • CH Elbeuf
    Elbeuf, France
    Recruiting
  • CHD Les Oudairies
    La Roche-sur-Yon, France
    Recruiting
  • CH La Rochelle
    La Rochelle, France
    Recruiting
  • Hôpital A. Mignot
    Le Chesnay, France
    Recruiting
  • Hôpital Robert Boulin
    Libourne, France
    Recruiting
  • CHU Dupuytren
    Limoges, France
    Recruiting
  • Hôpital de la Vallée - Service Pneumologie
    Longjumeau, France
    Recruiting
  • Centre Léon Bérard
    Lyon, France
    Recruiting
  • Hôpital Européen de Marseille
    Marseille, France
    Recruiting
  • Oncologie Thoracique Hôpital Nord
    Marseille, France
    Recruiting
  • GHEF Site de Meaux
    Meaux, France
    Recruiting
  • Centre d Oncologie de Gentilly
    Nancy, France
    Recruiting
  • Pneumologie CHR
    Orléans, France
    Recruiting
  • CH Annecy Genevois
    Pringy, France
    Recruiting
  • Pneumologie CHI Quimper
    Quimper, France
    Recruiting
  • CHU Hôpital Ponchailloux
    Rennes, France
    Recruiting
  • Pneumologie CHU Felix Guyon
    Saint-Denis, France
    Recruiting
  • Pneumologie CHU St Etienne
    Saint-Etienne, France
    Recruiting
  • Clinique Mutualiste
    Saint-Nazaire, France
    Recruiting
  • CHU de la Réunion
    Saint-Pierre, France
    Recruiting
  • CLCC Paul Strauss
    Strasbourg, France
    Recruiting
  • Hôpital d'Instruction des Armées Saint-Anne
    Toulon, France
    Recruiting
  • CHITS Toulon Sainte Musse
    Toulon, France
    Recruiting
  • Oncologie CHBA
    Vannes, France
    Recruiting
  • Hôpital Nord OUest
    Villefranche-sur-Saône, France
    Recruiting
  • CH Bastia
    Bastia, France
    Not yet recruiting
  • Pneumologie Centre François Baclesse
    Caen, France
    Not yet recruiting
  • CHU Hôpital Montpied
    Clermont-Ferrand, France
    Not yet recruiting
  • Polyclinique de Blois
    La Chaussée-Saint-Victor, France
    Not yet recruiting
  • Pneumologie Hôpital Cochin
    Paris, France
    Not yet recruiting
  • Pneumologie Hôpital Tenon
    Paris, France
    Not yet recruiting
  • Cantre Catalan d Oncologie
    Perpignan, France
    Not yet recruiting
  • Pneumologie Hôpital Charles Nicolle
    Rouen, France
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.