Evaluating Transcranial Magnetic Stimulation for Auditory Hallucinations in Schizophrenia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of repetitive Transcranial Magnetic Stimulation (rTMS) and continuous Theta Burst Stimulation (cTBS) in treating resistant auditory hallucinations in patients diagnosed with schizophrenia. It aims to assess the improvement of these hallucinations using the Auditory Hallucination Rating Scale (AHRS) in a naturalistic clinical setting, alongside standard antipsychotic treatments. Participants will be monitored for changes in their symptoms from baseline to the end of the treatment period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient over 18 years of age
* Patient diagnosed with schizophrenia according to DSM-V criteria (Diagnostic and Statistical Manual of Mental Disorder V5, 2013)
* Presence of auditory hallucinations: Resistant auditory hallucinations: resistance to treatment with 2 different well-conducted antipsychotics.
* Patient agreeing to participate in the study and having signed an informed consent
* Patient with French language skills
* Affiliation to a social security system
* Women of childbearing age must be on contraception and have a negative pregnancy test (βHCG)

Exclusion Criteria:

* Have a contraindication to MST: intracranial foreign body, unstabilized epilepsy, cochlear implant
* Presence of an unstabilized medical condition
* Pregnant woman (Women of childbearing age without effective contraception)
* Current or less than one month old engagement in another research protocol
* A person who is subject to a safeguard of justice measure
* An adult under curatorship
* Minor patients with mental health problems
* Pregnant or breastfeeding women
* A person in a social fragility (Persons deprived of liberty by a judicial or administrative decision, hospitalized persons)
* Persons incapable or unable to give consent

Where it's running

• Etablissement Public de Santé de Ville-Evrard
  Neuilly-sur-Marne, France Recruiting

Study contacts

• Principal investigator: Noomane BOUAZIZ — Clinical research unit, EPS Ville Evrard
• Study coordinator: Youcef Bencherif
• Email: urcve1@gmail.com
• Phone: +33 1 43 09 32 32

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.