Evaluating TQH2929 Injection for Generalized Pustular Psoriasis

Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Profile, and Efficacy of TQH2929 in Healthy Adult Subjects and Psoriasis Subjects

This study is testing a new injection called TQH2929 to see if it is safe and helps adults with active Generalized Pustular Psoriasis feel better during a flare-up.

Quick facts

• Phase: PHASE1
• Study type: Interventional
• Enrollment: 10 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (industry)
• Locations: 7 sites (Beijing, Beijing and 6 other locations)
• Trial ID: NCT06433531 on ClinicalTrials.gov

What this trial studies

This multicenter, single-group, open-label study aims to assess the safety and tolerability of TQH2929 injection at a dose of 900mg in adults with active Generalized Pustular Psoriasis (GPP). The study will include participants who meet specific criteria, including a documented history of GPP and a moderate-severe flare of the condition. The primary focus is on evaluating the injection's safety profile while also gathering preliminary efficacy data.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 75 with a documented history of Generalized Pustular Psoriasis and experiencing a moderate-severe flare.

Not a fit: Patients with primary plaque psoriasis vulgaris or those experiencing immediate life-threatening flares may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients suffering from Generalized Pustular Psoriasis.

How similar studies have performed: While this approach is being evaluated in this specific context, similar studies have shown promise in treating severe psoriasis conditions.

Eligibility criteria

Inclusion Criteria:

* Adults aged between 18 and 75 years (inclusive)，both male and female；
* A known and documented history of Generalized Pustular Psoriasis diagnosed with European Rare and Severe Psoriasis Expert Network (ERASPEN) criteria in 2017；
* Presenting with a moderate-severe flare of Generalized Pustular Psoriasis (GPP)
* Body mass index (BMI) within 18\~36 kg/m2；
* Major organ function is good;
* Patients must be able to understand and sign a written informed consent document;
* Patients must be able to complete study-related procedures and questionnaires;
* Female and male subjects of childbearing age should agree to use contraceptive measures during the study period and within 6 months after the end of the study; Female subjects need to serum pregnancy pregnancy test within 7 days before study enrollment.

Exclusion Criteria:

* Patients with primary plaque psoriasis vulgaris with pustules that are restricted to psoriatic plaques；
* Immediate life-threatening flare of Generalized Pustular Psoriasis or requiring intensive care treatment, according, to the judgment of the investigator；
* Computed Tomography of the chest shows active or occult tuberculosis or a history of contact with an open tuberculosis (TB) subject within the past 6 months. Subjects positive for tuber closes spot(T-SPOT) (or other tuberculosis diagnostic test) result;
* Active hepatitis during the screening period, or positive for hepatitis B surface antigen (HBsAg)；
* History of human immunodeficiency virus (HIV) infection, or positive HIV serological results at screening during screening；
* Positive antibodies to treponema pallidum during screening；
* History of serious infection leading to hospitalization or intravenous infusion of antibiotics or antiviral therapy within 3 months prior to baseline;
* Active systemic infections requiring systemic antibiotics or systemic antiviral therapy within 4 weeks prior to baseline;
* History of opportunistic infection and parasitic infection within 6 months prior to the screening period；
* History of herpes zoster infection within 2 months prior to baseline；
* Subject has known or suspected autoimmune disease;
* Receive major surgery within 4 weeks prior to the first dose;
* Subjects with any type of active malignancy or a history of malignancy (except cervical cancer or non-metastatic cutaneous squamous cell carcinoma, basal cell carcinoma and papillary thyroid carcinoma) that has been cured for more than 5 years prior to the screening period;
* Subjects have history of significant drug allergies；
* Use of the following medications within the prescribed time:

  1. Receive topical drugs for the treatment of skin diseases within 1 weeks prior to baseline;
  2. Receive systemic therapy within 4 weeks prior to baseline;
  3. Receive regular phototherapy within 4 weeks prior to baseline;
  4. Within 12 weeks prior to baseline, receive live (attenuated) vaccine;
  5. Receive antibiotics and antivirals within 4 weeks prior to baseline.
* People who are alcoholic, drug addicts, and known drug dependents;
* Pregnant or Breasting feeding subject;
* Received a blood transfusion within 4 weeks prior to the first dose;
* Subject is unable to tolerate intravenous infusion administration;
* During the period of participation in this study, participants had planned surgical procedures;
* Have participated in clinical trials of other drugs or medical devices within 4 weeks prior to baseline;
* In the judgment of the investigator or sponsoring medical auditor, it is believed that there are any medical or psychiatric symptoms that put the subject at risk, interfere with participation in the study, or interfere with the interpretation of the results of the study.

Where this trial is running

Beijing, Beijing and 6 other locations

• Peking University First Hospital — Beijing, Beijing, China (RECRUITING)
• Dermatology Hospital of Southern Medical Universitye — Guangzhou, Guangdong, China (NOT_YET_RECRUITING)
• The First Hospital of Hebei Medical University — Shijiazhuang, Hebei, China (NOT_YET_RECRUITING)
• The Second Hospital of Hebei Medical University — Shijiazhuang, Hebei, China (NOT_YET_RECRUITING)
• The First Hospital of China Medical University — Shenyang, Liaoning, China (NOT_YET_RECRUITING)
• Second People's Hospital of Chengdu — Chengdu, Sichuan, China (NOT_YET_RECRUITING)
• The Second Affiliated Hospital Zhejiang University School of Medicine — Hangzhou, Zhejiang, China (NOT_YET_RECRUITING)

Study contacts

• Study coordinator: Hang Li, Doctor

Conditions: Generalized Pustular Psoriasis