Evaluating the use of tranexamic acid in elderly patients with femoral neck fractures undergoing surgery
Official title: Efficacy and Safety of Retrograde Intraarticular Injection Via Drain Tube, Topical Soaking of Tranexamic Acid (TXA), or Placebo in Elderly Patients With Femoral Neck Fractures Undergoing Bipolar Hemiarthroplasty
Run by King Chulalongkorn Memorial Hospital · NCT06289478 · Data updated 2026-11-12
This study is testing if a medication called tranexamic acid can help older patients with hip fractures have less bleeding and need fewer blood transfusions during surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years and up |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | King Chulalongkorn Memorial Hospital Academic / other |
| Locations | 2 sites (Bangkok, Bangkok and 1 other locations) |
| Status | Recruiting |
| Started | July 3, 2024 |
| Main results expected | August 31, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | August 5, 2026 |
| Trial ID | NCT06289478 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are elderly patients over 60 years old with femoral neck fractures from low-energy mechanisms who are household ambulators.
✕Probably not a fit
Patients with allergies to TXA, history of venous thromboembolism, or significant blood disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the efficacy and safety of tranexamic acid (TXA) administered either through retrograde intraarticular injection or topical soaking in elderly patients with femoral neck fractures undergoing cementless bipolar hemiarthroplasty. The study aims to determine if TXA can reduce the need for blood transfusions during and after surgery. Participants will be randomly assigned to receive either the TXA treatment or a placebo, allowing researchers to compare outcomes effectively. The focus is on household ambulatory elderly patients who meet specific inclusion criteria.
Why it matters
Potential benefit: If successful, this study could significantly reduce the need for blood transfusions in elderly patients undergoing hip surgery.
How similar studies have gone: Previous studies have shown promising results with the use of tranexamic acid in reducing blood loss in surgical settings, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Elderly patients (age \> 60 years) * Femoral neck fractures from low energy mechanism * Household ambulator * Undergoing cementless bipolar hemiarthroplasty at KCMH * Informed consent Exclusion Criteria: * Allergy to TXA * History of VTE * History of hip surgery, pathological fracture, hip infection * Congenital or acquired coagulopathy * Hb \< 10 g/dL or Platelet \< 140,000
Where it's running
-
Faculty of Medicine, King Chulalongkorn Memorial Hospital
Bangkok, Bangkok, Thailand Recruiting -
Faculty of Medicine
Bangkok, Bangkok, Thailand Not yet recruiting
Study contacts
- Principal investigator: Kanyakorn Riewruja, Medical degree — Chulalongkorn University
- Study coordinator: Riewruja, Medical degree
- Email: kanyakorn.riew@gmail.com
- Phone: +66958644447
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.