Evaluating the use of PEEP in patients with acute respiratory failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the effectiveness of positive end-expiratory pressure (PEEP) in improving oxygenation and compliance in intubated patients with acute respiratory failure requiring mechanical ventilation. The study will evaluate whether the current practice of incrementally increasing PEEP levels leads to optimal outcomes, as previous findings from 1975 have not been validated in modern clinical settings. The research will involve monitoring patients who meet specific criteria, including those with acute hypoxemic respiratory failure. The goal is to determine if the historical application of PEEP remains relevant and beneficial in today's medical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Intubated patients requiring MV for \>24 h
* Age \>18 years
* Acute hypoxemic respiratory failure, defined as a PaO2/FiO2 \<300 with an FiO2 ≥0.3 and PEEP≥5 cmH2O.
* ARF caused by pulmonary insults.

Exclusion Criteria:

* ARF from non-pulmonary origin.
* Contraindications from high PEEP (severe head trauma or severe chest trauma).
* Patients that cannot maintained supine position.
* Uncorrected hypovolemia
* Hemodynamic instability

Where it's running

• Hospital Universitario Dr. Negrin
  Las Palmas de Gran Canaria, Las Palmas, Spain Recruiting
• Hospital Clinic
  Barcelona, Spain Not yet recruiting
• Hospital Universitario La Princesa
  Madrid, Spain Not yet recruiting

Study contacts

• Study coordinator: Jesús Villar, MD
• Email: jesus.villar54@gmail.com
• Phone: +34606860027

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effects of CPAP vs. High Flow Nasal Oxygen in ARDS Patients

  This study is testing whether using CPAP or high flow nasal oxygen helps people with acute respiratory distress syndrome breathe better and recover faster.

  Recruiting Hospital Clinic of Barcelona · Barcelona, Barcelona · NCT06694311

• High PEEP during noninvasive ventilation for hypoxemic respiratory failure

  This project will test whether higher PEEP settings on noninvasive ventilators help adults with hypoxemic respiratory failure improve oxygen levels.

  Recruiting Chongqing Medical University · Chongqing, Chongqing Municipality · NCT07503509

• Best starting flow for high-flow nasal cannula after extubation

  This trial tests four different ways of setting the initial flow on high-flow nasal cannula to see if one approach reduces breathing problems or the need to be put back on a ventilator after adults are extubated.

  Recruiting National Taiwan University Hospital · Taipei · NCT07007715

• High-flow oxygen therapy for patients on long-term oxygen therapy

  This study is testing if adding high-flow oxygen therapy at night can help people with COPD or interstitial lung disease who are already using long-term oxygen therapy feel better.

  Recruiting at 2 sites Skane University Hospital · Karlskrona, Blekinge County and 1 other locations · NCT06247397

• Sodium bicarbonate with bedside electrical impedance tomography to map lung blood flow in ventilated adults

  This project will try whether a small sodium bicarbonate injection combined with bedside electrical impedance tomography can map lung blood flow in adults on mechanical ventilation, compared with hypertonic saline.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07542366

• Feasibility of using a weight-adjusted saline bolus with electrical impedance tomography to map lung perfusion in children

  This pediatric pilot tests whether a carefully dosed saline bolus with electrical impedance tomography can map lung perfusion and ventilation distribution in kids with acute respiratory failure.

  Recruiting Hospices Civils de Lyon · Bron, France · NCT07532811

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.