Evaluating the success of vital pulp therapy methods for dental pulp exposure
The Effect of Different Risk Factors on the Success Rate of VPT: an Observational Prospective Cohort Study
This study is testing different ways to treat exposed dental pulp to see which methods work best for adults with teeth that can be saved.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Semmelweis University Academic / other |
| Locations | 1 site (Budapest) |
| Trial ID | NCT06844448 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the effectiveness of various vital pulp therapy (VPT) methods, including direct pulp capping, partial pulpotomy, and total pulpotomy, in preserving pulp vitality after pulp exposure. It will involve patients over 18 years old with restorable teeth and exposed pulp chambers, tracking success rates through clinical and radiological evaluations over a follow-up period of up to four years. Additionally, the study will investigate the influence of age and other co-factors on the success rates of these treatments.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old with at least one tooth that has a pulp chamber exposed during a dental procedure.
Not a fit: Patients with incomplete root development, deciduous teeth, or severe periodontal issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the most effective VPT methods, potentially improving dental treatment outcomes for patients with pulp exposure.
How similar studies have performed: While there have been studies on vital pulp therapy, this specific approach and its focus on age-related factors may provide novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 years of age who have at least one tooth with a pulp chamber that has been opened during a dental procedure or is likely to be opened during restoration of the tooth * The tooth is responsive to a sensitivity test with cold spray * The coronal part must be restorable * The periodontal depth around the tooth should be 0 according to the Dental Practicality Index Periodontal Treatment Need, i.e. the probing depth around the tooth should not be greater than 3.5 mm Exclusion Criteria: * Internal/external resorption in the tooth * If the root development of the tooth is not yet complete or if it is a deciduous tooth * Absolute isolation cannot be performed during the procedure * If pulp exposure does not occur even after complete removal of caries * The crown of the tooth cannot be restored * Periodontium surrounding tooth affected by moderate/severe marginal periodontitis (probing depth deeper than 3.5 mm) * Pulp exposure due to traumatic injury * Baseline radiograph shows signs of severe pulp palcification * Periapical lesion is around the root (Periapical index of the tooth \>2)
Where this trial is running
Budapest
- Department for Restorative Dentistry and Endodontics, Semmelweis University — Budapest, Hungary (Recruiting)
Study contacts
- Study coordinator: Melinda Zs Polyák, DMD
- Email: polyak.melinda@semmelweis.hu
- Phone: +36 1 459 1500
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.