Evaluating the success of vital pulp therapy methods for dental pulp exposure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the effectiveness of various vital pulp therapy (VPT) methods, including direct pulp capping, partial pulpotomy, and total pulpotomy, in preserving pulp vitality after pulp exposure. It will involve patients over 18 years old with restorable teeth and exposed pulp chambers, tracking success rates through clinical and radiological evaluations over a follow-up period of up to four years. Additionally, the study will investigate the influence of age and other co-factors on the success rates of these treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients over 18 years of age who have at least one tooth with a pulp chamber that has been opened during a dental procedure or is likely to be opened during restoration of the tooth
* The tooth is responsive to a sensitivity test with cold spray
* The coronal part must be restorable
* The periodontal depth around the tooth should be 0 according to the Dental Practicality Index Periodontal Treatment Need, i.e. the probing depth around the tooth should not be greater than 3.5 mm

Exclusion Criteria:

* Internal/external resorption in the tooth
* If the root development of the tooth is not yet complete or if it is a deciduous tooth
* Absolute isolation cannot be performed during the procedure
* If pulp exposure does not occur even after complete removal of caries
* The crown of the tooth cannot be restored
* Periodontium surrounding tooth affected by moderate/severe marginal periodontitis (probing depth deeper than 3.5 mm)
* Pulp exposure due to traumatic injury
* Baseline radiograph shows signs of severe pulp palcification
* Periapical lesion is around the root (Periapical index of the tooth \>2)

Where it's running

• Department for Restorative Dentistry and Endodontics, Semmelweis University
  Budapest, Hungary Recruiting

Study contacts

• Study coordinator: Melinda Zs Polyák, DMD
• Email: polyak.melinda@semmelweis.hu
• Phone: +36 1 459 1500

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using pulpal blood biomarkers to predict success of vital pulp therapy in symptomatic teeth

  This trial will test whether measuring metabolic biomarkers in pulpal blood at the time of carious pulp exposure can help predict 12-month success of vital pulp treatment in people aged 16–50 with symptomatic deep caries.

  Recruiting University of Baghdad · Baghdad · NCT07452614

• Impact of a 1-file rotary system on debris extrusion during root canal treatment

  This study tests whether using a single-file AF One system during root canal shaping reduces postoperative discomfort in teeth with irreversible pulpitis and mature roots.

  Recruiting Minia University · Minya, Minya Governorate · NCT07808684

• Direct pulp capping for deep and extremely deep caries in mature molars with reversible pulpitis

  This study tests whether direct pulp capping works similarly for deep versus extremely deep caries in adult, mature mandibular molars with reversible pulpitis.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07696702

• Buffered vs conventional local anesthesia for pain and anxiety during dental treatment in children with pulpitis

  This study tests whether buffered local anesthesia reduces pain and anxiety for school-aged children needing dental treatment for pulpitis.

  Recruiting Universidad Autonoma de San Luis Potosí · San Luis Potosí City, San Luis Potosí · NCT07638254

• Direct pulp capping in lower molars with side (proximal) versus top (occlusal) cavities: does the cavity location matter?

  This research will test whether direct pulp capping works as well for lower molars with side (proximal) cavities as for those with top (occlusal) cavities in people aged 15–40 who have reversible pulpitis.

  Recruiting Postgraduate Institute of Dental Sciences Rohtak · Rohtak, Haryana · NCT07578662

• Single Rotary File System vs Manual Instrumentation for Pulpectomy in Primary Molars

  This trial tests whether using a single rotary file system for pulpectomy in primary molars changes how children behave during the procedure compared with traditional manual instruments.

  Recruiting Cairo University · Cairo · NCT07415694

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.