Evaluating the role of PET-CT in managing invasive fungal infections
A Prospective Multicenter Study to Determine the Usefulness of Systematic 18-FDG-PET-TC for the Management of Invasive Fungal Infection (PETIFI Project)
This study is testing if a special type of scan called PET-CT can help doctors better manage invasive fungal infections compared to regular imaging methods.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 224 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Puerta de Hierro University Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 14 sites (Majadahonda, Madriid and 13 other locations) |
| Trial ID | NCT05688592 on ClinicalTrials.gov |
What this trial studies
This national multicenter prospective cohort study aims to assess the added value of 18F-FDG PET-CT in the management of invasive fungal infections (IFI). It will compare the effectiveness of PET-CT against conventional radiological studies in terms of disease characterization, staging, and monitoring treatment response. Participants will undergo a PET-CT scan as part of their diagnostic work-up, and researchers will analyze how this imaging technique influences patient management and prognostic evaluations. The study will include patients with fungemia and focal IFIs, following established diagnostic criteria.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with invasive fungal infections who can undergo a PET-CT scan.
Not a fit: Patients with active bacterial infections, recent surgeries in the affected area, or other medical conditions that may interfere with the study will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the management and outcomes of patients with invasive fungal infections by providing more accurate diagnostic and prognostic information.
How similar studies have performed: While the use of PET-CT in fungal infections is not widely established, preliminary literature suggests that similar approaches may yield promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * 18-year-old adult patients * who are admitted with a diagnosis of invasive fungal infection * who able to undergo a one 18F-FDG PET-CT * who give their informed consent. Exclusion criteria: * concomitant active bacterial infection likely to produce uptake in organs and tissues * recent surgery in the area of the IFI (in the previous 3 months) * other medical conditions that interfere with the development of the study ( e.g., inability to tolerate the performance of the test during the required time, pregnancy) * terminal situation.
Where this trial is running
Majadahonda, Madriid and 13 other locations
- Hospital Universitario Puerta de Hierro — Majadahonda, Madriid, Spain (Recruiting)
- Hospital de Bellvitge — Barcelona, Spain (Recruiting)
- Hospital Universitario Clinic — Barcelona, Spain (Recruiting)
- Hospital Universitario Virgen de las Nieves — Granada, Spain (Recruiting)
- Hospital Infanta Leonor Hospital — Madrid, Spain (Recruiting)
- Hospital Universitario Gregorio Marañón — Madrid, Spain (Recruiting)
- Hospital Universitario La Paz — Madrid, Spain (Recruiting)
- Hospital Unversitario Ramón y Cajal — Madrid, Spain (Recruiting)
- Hospital Virgen de la Victoria — Málaga, Spain (Recruiting)
- Hospital Morales Messeguer — Murcia, Spain (Not_yet_recruiting)
- Hospital Virgen de la Arrixaca — Murcia, Spain (Not_yet_recruiting)
- Hospital Universitario Central de Asturias — Oviedo, Spain (Recruiting)
- Hospital Unversitario de Salamanca — Salamanca, Spain (Recruiting)
- Hospital Universitario Virgenn de la Macarena — Seville, Spain (Recruiting)
Study contacts
- Principal investigator: Ana Fernández Cruz, MDPhD — Hospital Puerta de Hierro-Majadahonda
- Study coordinator: Andrea Gutiérrez Villanueva, MD
- Email: a.gutierrezv@hotmail.com
- Phone: +34618157518
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.