Evaluating the Reparel Knee Sleeve for Knee Osteoarthritis

Effects of Corticosteroid Injection Plus Reparel™ Knee Sleeve on Knee Osteoarthritis: a Randomized Clinical Trial

Not applicable Interventional University of Alabama at Birmingham · NCT04859764

This study is testing if wearing the Reparel knee sleeve can help people with knee osteoarthritis move better and feel less pain compared to a regular knee sleeve.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment74 (estimated)
Ages18 Years to 99 Years
SexAll
SponsorUniversity of Alabama at Birmingham Academic / other
Locations1 site (Birmingham, Alabama)
Trial IDNCT04859764 on ClinicalTrials.gov

What this trial studies

This study aims to assess the effectiveness of the Reparel knee sleeve in improving mobility, functionality, and pain relief in patients with knee osteoarthritis compared to a placebo knee sleeve. Participants will be randomly assigned to receive either the Reparel knee sleeve or a placebo and will be instructed to wear the sleeve during daily activities. They will also complete various questionnaires to evaluate their knee condition at multiple time points throughout the study. The goal is to determine if the anti-inflammatory properties of the sleeve provide significant benefits over standard treatment options.

Who should consider this trial

Good fit: Ideal candidates are individuals diagnosed with knee osteoarthritis who are seeking non-surgical treatment options.

Not a fit: Patients with bilateral knee osteoarthritis or those who have had prior surgery on the affected knee may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could offer a non-invasive treatment option that significantly improves quality of life for patients with knee osteoarthritis.

How similar studies have performed: While there have been various studies on knee osteoarthritis treatments, the specific use of anti-inflammatory sleeve technology is relatively novel and has not been extensively tested.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* osteoarthritis visible on knee radiograph
* patient opting for non-surgical treatment

Exclusion Criteria:

* bilateral symptomatic knee osteoarthritis
* prior surgery on the knee of interest
* hardware present on the knee of interest
* gross instability detected on physical exam
* malignancy in the knee of question

Where this trial is running

Birmingham, Alabama

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Osteoarthritis, Knee
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.