Evaluating the PADUA Prediction Score in patients with liver cirrhosis
Accuracy of PADUA PREDICTION SCORE in Thromboembolic Risk Stratification of Cirrhotic Patients Hospitalized in a Non-surgical Environment
This study is trying to see if the PADUA Prediction Score can help doctors figure out the risk of blood clots in patients with liver cirrhosis who are in the hospital.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 132 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Roma) |
| Trial ID | NCT05789654 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the predictive capability of the PADUA Prediction Score for the risk of developing venous thromboembolism in patients with liver cirrhosis who are admitted to non-surgical wards. It will involve a single center and be conducted in two phases: a retrospective analysis followed by a prospective case-control study. The study will also estimate the prevalence and incidence of venous thromboembolism and major bleeding events in this patient population, particularly in relation to thromboprophylaxis measures.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old with a diagnosis of liver cirrhosis who are hospitalized in a medical department.
Not a fit: Patients who are pregnant, undergoing double anticoagulation or antiplatelet therapy, or have contraindications to anticoagulation therapy will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve risk assessment and management strategies for venous thromboembolism in patients with liver cirrhosis.
How similar studies have performed: While the specific application of the PADUA Prediction Score in this context may be novel, similar studies have shown the importance of predictive scores in managing thromboembolic risks in various patient populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * written informed consent * age more than 18 years old * diagnosis of liver cirrhosis * hospitalization in a medical department Exclusion Criteria: * pregnancy * ongoing double anticoagulation or double antiplatelet therapy at the moment of hospitalization * controindications to anticoagulation therapy * hospitalization in surgical environnment
Where this trial is running
Roma
- Fondazione Policlinico Gemelli IRCCS — Roma, Italy (Recruiting)
Study contacts
- Study coordinator: Maria Assunta Zocco
- Email: mariaassunta.zocco@policlinicogemelli.it
- Phone: 00393470597805
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.