Evaluating the outcomes of cartilage repair surgery in the knee
Investigating the Biomechanical and Functional Outcomes of Autologous Chondrocyte Implantation: A Multi-centre Study
This study is testing how well cartilage repair surgery helps people with knee injuries feel and move better after the operation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 47 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Manchester Academic / other |
| Locations | 7 sites (Birmingham and 6 other locations) |
| Trial ID | NCT06921889 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the biomechanical and functional outcomes of autologous chondrocyte implantation (ACI) for patients with chondral defects in the knee. It aims to assess how this surgical procedure affects knee function and movement post-operation, providing valuable insights into recovery expectations and potential complications. By analyzing patient-reported outcomes alongside objective measures, the study seeks to enhance understanding of ACI's effectiveness and inform future treatment strategies. The research is crucial as untreated cartilage injuries can lead to arthritis, impacting long-term quality of life.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who have been diagnosed with a chondral injury to the knee and are listed for autologous chondrocyte implantation.
Not a fit: Patients under 18 years old or those listed for treatments other than ACI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide patients with clearer expectations regarding recovery and functional improvements after cartilage repair surgery.
How similar studies have performed: Previous studies have reported on patient outcomes following ACI, but this study aims to fill gaps in understanding biomechanical and functional results, making it a valuable addition to existing literature.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of a chondral injury to the knee by a consultant orthopaedic surgeon Participants must have this diagnosis, else they are not eligible for ACI surgery. * Listed for ACI for a chondral injury by a consultant orthopaedic surgeon Participants must be listed for ACI, as this is the treatment of interest in this research study * Over 18 years old Participants must be legally capable of providing informed consent for the study. Exclusion Criteria: * Listed for any treatment other than ACI Participants must be listed for ACI, as this is the treatment of interest in this research study * Under 18 years old. Participants must be legally capable of providing informed consent for the study.
Where this trial is running
Birmingham and 6 other locations
- Royal Orthopaedic Hospital — Birmingham, United Kingdom (Not_yet_recruiting)
- Addenbrooke's Hospital — Cambridge, United Kingdom (Not_yet_recruiting)
- Chapel Allerton Orthopaedic Centre — Leeds, United Kingdom (Recruiting)
- Trafford General Hospital — Manchester, United Kingdom (Recruiting)
- Southampton General Hospital — Southampton, United Kingdom (Not_yet_recruiting)
- Royal National Orthopaedic Hospital — Stanmore, United Kingdom (Recruiting)
- New Cross Hospital — Wolverhampton, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Gwenllian F Tawy, PhD — University of Manchester
- Study coordinator: Gwenllian F Tawy, PhD
- Email: gwenllian.tawy@manchester.ac.uk
- Phone: 01617462371
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.