Evaluating the outcomes of cartilage repair surgery in the knee

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the biomechanical and functional outcomes of autologous chondrocyte implantation (ACI) for patients with chondral defects in the knee. It aims to assess how this surgical procedure affects knee function and movement post-operation, providing valuable insights into recovery expectations and potential complications. By analyzing patient-reported outcomes alongside objective measures, the study seeks to enhance understanding of ACI's effectiveness and inform future treatment strategies. The research is crucial as untreated cartilage injuries can lead to arthritis, impacting long-term quality of life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of a chondral injury to the knee by a consultant orthopaedic surgeon Participants must have this diagnosis, else they are not eligible for ACI surgery.
* Listed for ACI for a chondral injury by a consultant orthopaedic surgeon Participants must be listed for ACI, as this is the treatment of interest in this research study
* Over 18 years old Participants must be legally capable of providing informed consent for the study.

Exclusion Criteria:

* Listed for any treatment other than ACI Participants must be listed for ACI, as this is the treatment of interest in this research study
* Under 18 years old. Participants must be legally capable of providing informed consent for the study.

Where it's running

• Chapel Allerton Orthopaedic Centre
  Leeds, United Kingdom Recruiting
• Trafford General Hospital
  Manchester, United Kingdom Recruiting
• Royal National Orthopaedic Hospital
  Stanmore, United Kingdom Recruiting
• New Cross Hospital
  Wolverhampton, United Kingdom Recruiting
• Royal Orthopaedic Hospital
  Birmingham, United Kingdom Not yet recruiting
• Addenbrooke's Hospital
  Cambridge, United Kingdom Not yet recruiting

Study contacts

• Principal investigator: Gwenllian F Tawy, PhD — University of Manchester
• Study coordinator: Gwenllian F Tawy, PhD
• Email: gwenllian.tawy@manchester.ac.uk
• Phone: 01617462371

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Comparing MACI and microfracture treatments for knee cartilage defects in teens

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.