Evaluating the long-term effectiveness of oral appliances for obstructive sleep apnea

Long Term Oral Appliance Therapy Effectiveness for Obstructive Sleep Apnea: A Multicenter Cohort Study

Observational University of British Columbia · NCT02410850

This study is testing how well oral appliances help people with obstructive sleep apnea over the long term and whether they can improve heart health compared to other treatments.

Quick facts

Study typeObservational
Enrollment1000 (estimated)
Ages18 Years to 90 Years
SexAll
SponsorUniversity of British Columbia Academic / other
Locations1 site (Vancouver, British Columbia)
Trial IDNCT02410850 on ClinicalTrials.gov

What this trial studies

This study assesses the long-term effectiveness of oral appliance therapy in patients diagnosed with obstructive sleep apnea (OSA). It aims to analyze the impact of this non-invasive treatment on cardiovascular morbidity and mortality. The research focuses on patients who are currently prescribed oral appliances, exploring their adherence and the overall benefits of this therapy compared to other treatments like CPAP. The study is observational and will gather data over an extended period to evaluate outcomes.

Who should consider this trial

Good fit: Ideal candidates for this study are adults currently prescribed oral appliances for their obstructive sleep apnea.

Not a fit: Patients under 18 years of age or those who do not understand English may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide evidence supporting the use of oral appliances as a viable long-term treatment option for patients with obstructive sleep apnea, potentially improving their cardiovascular health.

How similar studies have performed: While oral appliance therapy is recognized as a treatment for OSA, this study aims to fill a gap in long-term effectiveness data, making it a novel approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients are currently prescribed Oral Appliance for their Obstructive Sleep Apnea

Exclusion Criteria:

* Patients under the age of 18 years.
* Patients that do not understand the English language.
* Patients that refuse to sign the informed consent for any reason.

Where this trial is running

Vancouver, British Columbia

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Obstructive Sleep ApneaOral Applianceobjective adherencecardiovascular eventscardiovascular mortalitycerebrovascular mortalitycost effectiveness
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.