Evaluating the impact of perinephric fat thickness on kidney function after donation
Prospective Study to Assess the Risks of Perinephric Fat Thickness on Adverse Renal Outcomes Post Donor Nephrectomy - ProActive Study
This study is testing if the thickness of fat around the kidneys affects kidney function and blood pressure in people who are donating a kidney.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT06886087 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate whether perirenal fat thickness (PRAT) serves as a marker for visceral obesity and its effects on kidney function and blood pressure in living kidney donors. Participants will include individuals scheduled for nephrectomy, with specific BMI and PRAT thickness criteria. The study will assess PRAT morphology and inflammation, correlating these factors with renal outcomes and hypertension over a period of 4-6 months post-donation. Data will be collected through medical records and various health assessments during a screening visit.
Who should consider this trial
Good fit: Ideal candidates are living kidney donors aged 18 and older with specific BMI and PRAT thickness measurements.
Not a fit: Patients who do not meet the BMI and PRAT thickness criteria or those with significant weight changes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the management of blood pressure and obesity in living kidney donors, enhancing their long-term health outcomes.
How similar studies have performed: While the specific approach of correlating PRAT thickness with renal outcomes in living kidney donors is novel, similar studies have explored the impact of obesity on kidney function with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants in this study will be restricted to living kidney transplant donors (LKDs). . Exclusion Criteria: * Those who do not meet Mayo Clinic Rochester's clinical criterion for donor nephrectomy. * \>10% weight change between the donor evaluation and donor nephrectomy * Individuals who are pregnant or are planning to become pregnant * Inability to comply with study procedures or any condition that, in the opinion of the investigator, could increase the patient's risk by participating in the study or confound the outcome of the study.
Where this trial is running
Rochester, Minnesota
- Mayo Clinic — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Aleksandra Kukla, MD — Mayo Clinic
- Study coordinator: Jackie Reiter
- Email: reiter.jacqulyn@mayo.edu
- Phone: 507-538-2224
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.