Evaluating the Impact of Compressed Sensing on MRI Signals
Évaluation de l'Impact du Compressed Sensing Sur le Signal QSM
This study is testing if adding new MRI techniques can improve the quality of scans for people with multiple sclerosis and others needing brain MRIs.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris) |
| Trial ID | NCT04907487 on ClinicalTrials.gov |
What this trial studies
This observational study involves patients undergoing routine MRI scans who will complete additional sequences to assess the impact of compressed sensing on MRI signal quality. Participants will receive standard MRI sequences along with four additional sequences that last a total of 25 minutes. The study aims to enhance the understanding of MRI imaging techniques, particularly in patients with multiple sclerosis and those requiring brain MRIs. The goal is to evaluate how these additional sequences can improve diagnostic capabilities.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with multiple sclerosis or those needing a brain MRI who are at low risk for inflammatory CNS disease.
Not a fit: Patients who are pregnant, breastfeeding, or under legal protection measures may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved MRI imaging techniques, enhancing diagnostic accuracy for patients.
How similar studies have performed: While the approach of using compressed sensing in MRI is gaining traction, this specific evaluation is relatively novel and has not been extensively tested in similar studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For patients with MS: * Patient over 18 years old * Presenting MS defined according to McDonald's revised criteria for spatial and temporal clinical or radiological dissemination \[16\], * Should benefit as part of the care of an MRI examination with or without injection of gadolinium * Express consent to participate in the study * Affiliate or beneficiary of a social security scheme For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease: * Patient over 18 years old * Should benefit as part of the care of an MRI examination with or without injection of gadolinium * Express consent to participate in the study * Affiliate or beneficiary of a social security scheme Exclusion Criteria: * For patients with MS: * Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease: * Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman * Patient with inflammatory and / or demyelinating pathology of the CNS Secondary exclusion criteria : * Motion artefact not allowing interpretation of images * Patient who did not perform one of the following sequences: 3D T1 TFE, 3D FLAIR (for MS patients), SWI QSM 1.0iso 8 echoes. Secondarily excluded patients will be replaced.
Where this trial is running
Paris
- Hhopital fondation adolphe de rothschild — Paris, France (Recruiting)
Study contacts
- Study coordinator: amélie YAVCHITZ
- Email: ayavchitz@for.paris
- Phone: 0148036454
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.