Evaluating the impact of calcification on coronary artery procedures
Characteristics of Calcification in a Chronic Total Occlusion on Computed Tomography Coronary Angiogram and Percutaneous Coronary Intervention Outcomes- a Single Centre Observational Study
This study looks at how the amount and type of calcium buildup in heart arteries affects the success of a specific heart procedure in patients with blocked arteries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sandwell & West Birmingham Hospitals NHS Trust Academic / other |
| Locations | 1 site (Birmingham, West Midlands) |
| Trial ID | NCT06414551 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the relationship between calcification characteristics identified through Computed Tomography Coronary Angiography (CTCA) and the outcomes of Percutaneous Coronary Intervention (PCI) in patients with Chronic Total Occlusion (CTO) of the coronary artery. The study will retrospectively analyze data from patients who underwent both CTO PCI attempts and CTCA at the Sandwell and West Birmingham NHS Trust over the past five years. Key factors such as the site, density, and quantity of calcification will be correlated with PCI success and failure rates, utilizing statistical methods for analysis.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have undergone a CTO PCI attempt and a CTCA within the last five years.
Not a fit: Patients who are under 18 years old or who did not undergo a CTCA will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of how calcification affects PCI outcomes, potentially leading to improved treatment strategies for patients with CTO.
How similar studies have performed: Other studies have shown success in correlating imaging characteristics with procedural outcomes, suggesting that this approach is promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients meeting all the below criteria will be included * ≥18 years * Previous CTO PCI attempt in the last 5 years * Undergone CTCA either pre or post CTO PCI * Adequate CTCA images for analysis Exclusion Criteria: * Patients meeting any of the following criteria will be excluded * \<18 years of age * Did not undergo CTCA * Inadequate/degraded CTCA images
Where this trial is running
Birmingham, West Midlands
- Birmingham City Hospital, Sandwell and West Birmingham NHS Trust — Birmingham, West Midlands, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Vinoda Sharma, FRCP — Sandwell & West Birmingham Hospitals NHS Trust
- Study coordinator: Vinoda Sharma, FRCP
- Email: vinodasharma@nhs.net
- Phone: +44(0)1215075841
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.