Evaluating the impact of brain imaging and neurological exams in patients with infectious endocarditis
Prospective Pilot Study Evaluating the Prognostic Impact of a Neuro-vascular Examination Associated with Cerebral MRI in the Acute Phase of Infectious Endocarditis
This study is testing if brain scans and neurological exams can help doctors make better treatment decisions for people with infectious endocarditis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 1 site (Bron) |
| Trial ID | NCT05378126 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the prognostic significance of a neuro-vascular examination combined with cerebral MRI in patients diagnosed with infectious endocarditis. It focuses on understanding how brain imaging can reveal ischemic lesions and microbleeds, which may influence treatment decisions. The study seeks to involve vascular neurologists in the management of these patients, addressing the current gap in neurological data related to infectious endocarditis. By creating a neurological cohort, the research aims to clarify the role of neurological assessments in improving patient outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients diagnosed with infectious endocarditis according to the Dukes Criteria.
Not a fit: Patients who are admitted for neurovascular emergencies or have contraindications for MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the management and treatment strategies for patients with infectious endocarditis, potentially reducing complications such as stroke.
How similar studies have performed: While there is limited data on the specific combination of neuro-vascular assessments and MRI in this context, the study addresses a significant gap in existing literature, suggesting a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients * Certain infectious endocarditis according to Dukes Criteria * Signed informed consent Exclusion Criteria: * Hospital admission due to neurovascular emergency * MRI contraindications * Pregnant or women of childbearing age who were not using contraception (oral diagnosis), * Patient without health coverage, * Patient under legal protection.
Where this trial is running
Bron
- Stroke Unit, Pierre Wertheimer hospital, GHE Hospices Civils de Lyon — Bron, France (Recruiting)
Study contacts
- Study coordinator: Elodie ONG, Dr
- Email: elodie.ong@chu-lyon.fr
- Phone: 04 72 35 78 18
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.