Evaluating the HPV vaccine's safety and effectiveness in young Chinese females

Evaluating the Immunogenicity and Safety of Quadrivalent Human Papillomavirus Recombinant Vaccine (Type 6, 11, 16, 18) in Healthy Chinese Female Subjects Aged 9 to 26 Years: A Phase 3, Open-label, Non-randomized Clinical Trial

This study is testing the safety and effectiveness of the HPV vaccine in healthy young Chinese females aged 9 to 26 to see if fewer doses can work as well as the standard three doses.

Quick facts

• Phase: Phase 3
• Study type: Interventional
• Enrollment: 1348 (estimated)
• Ages: 9 Years to 26 Years
• Sex: Female
• Sponsor: Shanghai Bovax Biotechnology Co., Ltd. (Industry-sponsored)
• Locations: 1 site (Mianyang, Sichuan)
• Trial ID: NCT05027776 on ClinicalTrials.gov

What this trial studies

This phase 3 study aims to assess the immunogenicity and safety of the Quadrivalent HPV recombinant vaccine in healthy Chinese females aged 9 to 26 years. Participants will receive either a 2-dose or 3-dose schedule of the vaccine, with the study lasting approximately 60 months and involving nine to eleven scheduled visits. The study will compare the immune response of younger girls receiving fewer doses to that of older women receiving the standard three doses, while also monitoring the vaccine's safety profile.

Who should consider this trial

Good fit: Ideal candidates for this study are healthy Chinese females aged 9 to 26 years who meet specific eligibility criteria.

Not a fit: Patients who are not healthy or who do not meet the age and other eligibility criteria may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance vaccination strategies against HPV, potentially reducing the incidence of cervical and other HPV-related cancers in young women.

How similar studies have performed: Other studies have shown success with similar HPV vaccination approaches, indicating the potential for positive outcomes in this study as well.

Eligibility criteria

Inclusion Criteria:

1. Healthy Chinese females aged 9 to 26 years; Provide legal identification;
2. The subject voluntarily agrees to enroll in this study. If the subject is a minor, both the subject and subject's legal guardian should voluntarily agree to enroll in this study and sign an informed consent form;
3. Had a negative urine pregnancy test on the day of enrollment, among the subjects of childbearing age; Not in the duration of breast-feeding and no birth plan within 7 months; According to the investigator's judgment that there is no possibility of pregnancy at that time: subjects have taken effective contraception, or asexual life after the last menstrual period, or use IUD, or had undergone ligation; subjects agree to continue take effective contraception such as taking OCS and condom use;
4. No fever symptoms on the day of enrollment (aged\> 14 years old, axillary temperature\<37.3°C; aged ≤ 14 years old, axillary temperature\<37.5°C );
5. Be able to understand the study procedures and promise to participate in regular follow-ups under the requirements;

Exclusion Criteria:

1. Received marketed HPV vaccine or plan to receive marketed HPV vaccine during this study period or have enrolled in HPV vaccine clinical trials;
2. Enrolling or plan to enroll in other clinical trials (drug or vaccine);
3. History of positive test to HPV, history of cervical cancer (e.g. abnormal screening test results, abnormal cervical biopsy results, including CIN, LSIL, and cervical cancer) or history of pelvic radiotherapyherpes;
4. History of diseases related to HPV infection (e.g. genital warts, VIN, VaIN, and related cancers) or history of STDs, including syphilis, gonorrhea, genital herpes, Mycoplasma genitalium, Lymphgranuloma Venereum, granuloma inguinale, etc.;
5. Known allergy to any vaccine components or history of severe allergic diseases requiring treatment, including shock, laryngeal edema, urticarial, Henoch-Schonlein purpura, Arthus reaction, etc.;
6. Had primary or acquired immunodeficiency such as HIV, SLE, JRA, etc;
7. History of epilepsy and convulsions (except fever convulsions in children under 5 years of age);
8. Subjects with existing infectious diseases such as TB, viral hepatitis, and/or HIV infection; or existing liver or kidney conditions, CVDs, and malignancy;
9. Untreated/uncontrolled hypertension before vaccination (aged 9 to 17 years: systolic BP≥120mmHg and/or diastolic BP≥80mmHg; aged more than 18 years: Systolic BP≥140mmHg and/or diastolic BP ≥90mmHg);
10. With prohibitive contraindications such as Thrombocytopenia or coagulopathy;
11. Asplenic, functionally asplenic, or splenectomy caused by any condition;
12. Received immunosuppressive treatment within one month before study such as long-term glucocorticoid use(≥2mg per kg per day, lasted more than two wks), or plan to receive such treatment from month 0 to month 7；
13. Receipt of immune globulin or blood-related products within 3 months; or plan to receive such products during this study period（month 0 to month 7）;
14. Within 3 days prior to vaccination, have an acute disease or are in the acute attack of a chronic disease or have used antipyretic, analgesic and anti-allergic drugs (such as: acetaminophen, ibuprofen, aspirin, loratadine, ceti Rizine, etc.);
15. Receipt of inactivated, RNA, and recombinant vaccines within 14 days, live vaccines within 28 days;
16. Subjects with existing mental illness, History of mental illness, or Family History;
17. According to the investigator's judgment, the subject has any condition may interfere with process of evaluation or participating in this study cannot guarantee the object's maximum benefit.

Where this trial is running

Mianyang, Sichuan

• Center for Disease Control and Prevention — Mianyang, Sichuan, China (Recruiting)

Study contacts

• Study coordinator: Ting Huang

Conditions HPV Infections; Cervical Cancer Stage IIa; Vaginal Cancer; Genital Wart; CIN1; CIN2; CIN3; Human papillomavirus