Evaluating the effects of vitamin C on bone preservation after tooth extraction
Evaluation of Dentin Graft and I-PRF With and Without Vitamin C for Post-extraction Socket Preservation. A Randomized Controlled Clinical Trial
This study is testing if adding vitamin C to a bone graft after tooth extraction can help preserve bone better than just using the graft alone.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 26 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06569264 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the impact of adding vitamin C to autogenous demineralized dentin graft and i-PRF on marginal bone loss following tooth extraction. Participants will be divided into two groups: one receiving the graft with vitamin C and the other receiving the graft without it. The study will evaluate clinical and radiographic outcomes over a six-month follow-up period. The hypothesis is that vitamin C may enhance osteoblast activity and improve soft tissue quality, leading to better socket preservation.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with non-restorable teeth requiring extraction and alveolar preservation prior to dental implant placement.
Not a fit: Patients with systemic conditions affecting healing, such as diabetes or those undergoing chemotherapy, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved bone preservation and better outcomes for patients requiring dental implants after tooth extraction.
How similar studies have performed: While the use of vitamin C in bone preservation is promising, this specific combination of treatments has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Inclusion criteria: * ≥ 18 years of age. * Single extraction of non-molar teeth with periodontally healthy adjacent teeth. * Non-contributory medial history. * Non- restorable teeth indicated for extraction. * Requiring alveolar preservation after tooth extraction prior to placement of dental implant. * Participants that are eligible for immediate implantation, yet having factors that are hindering these patients from immediate placement of an implant at the time of extraction (ex: Financial related factors - psychological psychological factors - time related factors). * Cooperative patients who are willing to commit for 3 months follow up. Exclusion Criteria: * Pregnant female. * Acute infection at extraction site. * Systemic conditions affecting healing (e.g., diabetes, medications as bisphosphonates...) * A participant who had radiotherapy or chemotherapy. * Psychiatric patient, or with a learning disability, or unable to give consent.
Where this trial is running
Cairo
- Faculty of Dentistry, Cairo University — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: Noha Barwa, Bachelor — Cairo University
- Study coordinator: Noha A Barwa, Bachelor
- Email: noha.ahmed@dentistry.cu.edu.eg
- Phone: +201116010759
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.