Evaluating the effects of two medications for high blood pressure
Official title: A Multicenter, Randomized, Double-blind, Phase III Study to Evaluate the Efficacy and Safety of AD-227A and AD-227B Combination Treatment in Patients with Essential Hypertension
Run by Addpharma Inc. · NCT06441630 · Data updated 2026-11-12
This study is testing whether a combination of two new medications can help people with high blood pressure feel better and stay safe.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 251 (estimated) |
| Sponsor | Addpharma Inc. Industry-sponsored |
| Locations | 1 site (Seoul) |
| Status | Recruiting |
| Started | July 31, 2024 |
| Main results expected | September 2025 |
| Study ends | September 2025 |
| Registry record updated | February 4, 2025 |
| Trial ID | NCT06441630 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults diagnosed with essential hypertension who can provide informed consent.
✕Probably not a fit
Patients with secondary hypertension will not benefit from this study as it specifically targets essential hypertension.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to assess the efficacy and safety of the combined use of AD-227A and AD-227B in treating patients with essential hypertension. Participants will receive either the active medications or placebos to determine the effectiveness of the treatment regimen. The study is designed to gather data on how well these medications work together and their safety profile in a Phase 3 setting. The trial will involve a diverse group of patients who meet specific inclusion criteria.
Why it matters
Potential benefit: If successful, this study could provide a new effective treatment option for patients suffering from essential hypertension.
How similar studies have gone: Other studies have shown promise in the treatment of essential hypertension with similar medication combinations, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Signed informed consent * Patients with Essential Hypertension * Other inclusions applied Exclusion Criteria: * Patient with Secondary Hypertension * Other exclusions applied
Where it's running
-
Gangnam CHA Medical Center
Seoul, South Korea Recruiting
Study contacts
- Principal investigator: Chong-Jin Kim — Gangnam CHA Medical Center
- Study coordinator: JeongEun Park
- Email: parkje@addpharma.co.kr
- Phone: +82-31-891-6989
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Isometric wall squat exercise to lower blood pressure in adults with hypertension
We’re testing whether doing isometric wall squats at home for 12 weeks can help lower 24-hour blood pressure in adults with essential hypertension.
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MWX401 Injection in healthy adults and people with mild hypertension
This early Phase 1 study tests a single subcutaneous dose of MWX401 to see if it's safe and tolerable in healthy Chinese adults and in adults with mild high blood pressure.
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Single-use intravascular ultrasound (IVUS) ablation for primary hypertension
This will test whether a single-use intravascular ultrasound ablation device can safely lower blood pressure in adults with primary (essential) hypertension who are on a standardized ARB/CCB-based medication regimen.
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Study of childhood high blood pressure and its genetic factors
This study is trying to find out how genes affect high blood pressure in kids by looking at their health over several years to help create better treatments.
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CKD-202A (sacubitril/valsartan) for adults with high blood pressure
This trial will test whether CKD-202A (sacubitril/valsartan) controls blood pressure safely in adults with essential hypertension compared with valsartan.
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Treatment for severe high blood pressure using targeted artery blockage
This study is testing a new procedure to see if blocking specific arteries can help people with severe high blood pressure that hasn't improved with regular medications.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.