Clinical trial Recruiting at 1 site Phase 3 Interventional Ages 19 and up

Evaluating the effects of two medications for high blood pressure

Official title: A Multicenter, Randomized, Double-blind, Phase III Study to Evaluate the Efficacy and Safety of AD-227A and AD-227B Combination Treatment in Patients with Essential Hypertension

Run by Addpharma Inc. · NCT06441630 · Data updated 2026-11-12

This study is testing whether a combination of two new medications can help people with high blood pressure feel better and stay safe.

More Essential Hypertension trials

Quick facts

PhasePhase 3
Study typeInterventional
Ages19 Years and up
SexAll
Enrollment251 (estimated)
SponsorAddpharma Inc.
Industry-sponsored
Locations1 site (Seoul)
StatusRecruiting
StartedJuly 31, 2024
Main results expectedSeptember 2025
Study endsSeptember 2025
Registry record updatedFebruary 4, 2025
Trial IDNCT06441630 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults diagnosed with essential hypertension who can provide informed consent.

Probably not a fit

Patients with secondary hypertension will not benefit from this study as it specifically targets essential hypertension.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the efficacy and safety of the combined use of AD-227A and AD-227B in treating patients with essential hypertension. Participants will receive either the active medications or placebos to determine the effectiveness of the treatment regimen. The study is designed to gather data on how well these medications work together and their safety profile in a Phase 3 setting. The trial will involve a diverse group of patients who meet specific inclusion criteria.

Why it matters

Potential benefit: If successful, this study could provide a new effective treatment option for patients suffering from essential hypertension.

How similar studies have gone: Other studies have shown promise in the treatment of essential hypertension with similar medication combinations, indicating potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Signed informed consent
* Patients with Essential Hypertension
* Other inclusions applied

Exclusion Criteria:

* Patient with Secondary Hypertension
* Other exclusions applied

Where it's running

  • Gangnam CHA Medical Center
    Seoul, South Korea
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.