Evaluating the effects of stopping beta-blockers after heart attack

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to determine if stopping beta-blocker therapy after at least one year is as effective as continuing the treatment in patients who have experienced an acute myocardial infarction but do not have heart failure or left ventricular systolic dysfunction. It is a prospective, open-label, randomized, multicenter, noninferiority trial designed to provide clarity on the optimal duration of beta-blocker therapy in this patient population. The trial will compare outcomes between those who discontinue beta-blockers and those who continue the therapy, addressing a significant gap in current clinical guidelines.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subject must be at least 19 years of age.
* Subject who have been continuing β-blocker therapy for at least 1 year after acute myocardial infarction regardless of the time of diagnosis
* Subject is able to verbally confirm understandings of risks and benefits of this trial, and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure.

Exclusion Criteria:

* Subject whose left ventricle ejection fraction was less than 40% from echocardiography performed after acute myocardial infarction or who have never received echocardiography.
* Treatment history of heart failure
* Contraindication to β-blocker therapy (history of symptomatic bronchial asthma or chronic obstructive pulmonary disease, 2nd or 3rd degree AV block, cardiac pacemaker implantation, or other cases where β-blocker cannot be used under the judgment of the clinician)
* Non-cardiac co-morbid conditions are present with life expectancy \<1 year or that may result in protocol non-compliance (per site investigator's medical judgment).
* History of atrial fibrillation
* Pregnancy or breast feeding

Where it's running

• Samsung Medical Center
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Joo-Yong Hahn, MD,PhD — Samsung Medical Center
• Study coordinator: Joo-Yong Hahn, MD,PhD
• Email: jyhahn@skku.edu
• Phone: 82-2-3410-6653

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.