Evaluating the effects of chemotherapy on bladder function in childhood cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess how two specific chemotherapy drugs, vincristine and doxorubicin, impact bladder function and urine composition in children who have survived cancer. The study will involve children aged 5-13 years who have completed chemotherapy at least one year prior and will utilize non-invasive urodynamic testing, urinary proteomic screening, and a survey to evaluate bladder dysfunction symptoms. The researchers hypothesize that survivors exposed to these chemotherapies will report higher incidences of bladder dysfunction and show significant differences in urinary biomarkers compared to those without such symptoms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children aged 5-13 years old
* A history of cancer
* Treatment with a chemotherapy regimen including VCR and/or DOX
* Completion of chemotherapy at least one year prior to study enrollment and survey completion.

Exclusion Criteria:

* Patients with a:
* Primary pelvic tumor
* Pelvic irradiation
* Pre-existing bladder/bowel dysfunction
* Spinal defects
* Neurologic disorder
* Neuro-oncologic tumor or brain metastasis
* Cyclophosphamide or ifosfamide therapy

Where it's running

• Children's Hospital Colorado
  Aurora, Colorado, United States Recruiting

Study contacts

• Principal investigator: Nicholas Cost, MD — Children's Hospital Colorado
• Study coordinator: Gemma Beltran
• Email: gemma.beltran@childrenscolorado.org
• Phone: (720) 777-4418

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.