Clinical trial Recruiting at 2 sites Observational

Evaluating the effects of antihistamines and amantadine on COVID-19 outcomes

Official title: Evaluation of Treatments With Antihistamines and Amantadine in the Evolution of the SARS-CoV-2 Infection

Run by Consorci Sanitari de Terrassa · NCT05504057 · Data updated 2026-11-12

This study is testing whether taking antihistamines or amantadine helps older patients in nursing homes have better outcomes with COVID-19 compared to those who don't take these medications.

More COVID-19 trials

Quick facts

Study typeObservational
SexAll
Enrollment140660 (estimated)
SponsorConsorci Sanitari de Terrassa
Academic / other
Locations2 sites (Terrassa, Barcelona and 1 other locations)
StatusRecruiting
StartedMarch 1, 2020
Main results expectedJanuary 19, 2025
Study endsFebruary 24, 2028
Registry record updatedApril 3, 2026
Trial IDNCT05504057 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients who are on chronic treatment with antihistamines or amantadine.

Probably not a fit

Patients not receiving chronic treatment with antihistamines or amantadine may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to quantify the rates of symptomatic COVID-19 infection, hospital admissions, and survival among patients who are chronically treated with antihistamines or amantadine. The research will analyze data from patients in nursing homes and compare their outcomes with a control group from the Terrassa Health Consortium. By stratifying results by age groups, the study seeks to determine the potential protective roles of these medications in the evolution of COVID-19.

Why it matters

Potential benefit: If successful, this study could identify effective treatments that improve outcomes for COVID-19 patients.

How similar studies have gone: Previous reports have suggested potential benefits of antihistamines and amantadine in COVID-19 cases, indicating that this approach may have merit.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria: Patients having chronic treatment with antihistamines or amantadine -

Exclusion Criteria: None

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Where it's running

  • Hospital de Terrassa
    Terrassa, Barcelona, Spain
    Recruiting
  • Hospital of Terrassa
    Terrassa, Barcelona, Spain
    Recruiting

Study contacts

  • Principal investigator: Anna Puigdellívol, PhD — Terrassa Health Consortium
  • Study coordinator: Anna Puigdellivol, Ph.D
  • Email: apuigdellivol@cst.cat
  • Phone: 34-93-5884555

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.