Evaluating the effects of a surgical technique on gastrointestinal function in patients with aortic dissection
Impact of Retrograde Inferior Vena Cava Perfusion on Gastrointestinal Function in Patients Undergoing Surgical Repair for Acute Type A Aortic Dissection: A Study Protocol and Prospective Evaluation.
The Second Hospital of Nanjing Medical University · NCT06434987
This study is testing if a special surgical technique called Retrograde Inferior Vena Cava Perfusion can help improve gut function and reduce complications for patients recovering from surgery for aortic dissection.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | The Second Hospital of Nanjing Medical University (other) |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Nanjing, Jiangsu) |
| Trial ID | NCT06434987 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of Retrograde Inferior Vena Cava Perfusion (RIVP) on gastrointestinal function in patients undergoing surgical repair for Acute Type A Aortic Dissection (ATAAD). It aims to assess whether RIVP can reduce ischemic reperfusion injury and inflammatory responses that may compromise gastrointestinal integrity during and after surgery. The study will compare postoperative gastrointestinal complications in patients receiving RIVP alongside standard surgical procedures. By focusing on this often-overlooked aspect of patient recovery, the research seeks to enhance overall outcomes following ATAAD repair.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-70 who are scheduled for surgical repair of Acute Type A Aortic Dissection under cardiopulmonary bypass.
Not a fit: Patients with pre-existing gastrointestinal conditions or those on certain medications that affect gut microbiome may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved gastrointestinal health and recovery for patients undergoing surgery for aortic dissection.
How similar studies have performed: Previous studies have shown promising results with RIVP in reducing organ dysfunction, suggesting potential for success in this area, although specific gastrointestinal outcomes require further investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients undergoing ATAAD repair under CPB. 2. Age: 18-70 years 3. Give consent Exclusion Criteria: 1. Variables that can influence gut microbiome like antibiotics or probiotics 2 weeks prior to surgery 2. On chemotherapy 3. Evidence of pre-operative malperfusion of the GI system 4. Presence of GI any pathology (IBD,GERD,PU) 5. Continuous enteral feeding prior to surgery 6. Refuse to participate in the study
Where this trial is running
Nanjing, Jiangsu
- The Second Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu, China (RECRUITING)
Study contacts
- Principal investigator: Sanaa Azim — The Second Affiliate Hospital of Nanjing Medical University
- Study coordinator: Sanaa Azim
- Email: sanaazim@yandex.com
- Phone: +8615679202116
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Type A Aortic Dissection, Acute Type A Aortic Dissection