Evaluating the effectiveness of the Invisalign Palatal Expander system

Treatment Effects of Invisalign Palatal Expander System and Hyrax Palatal Expander - A Randomized Controlled Trial

NA · University of the Pacific · NCT06414863

This study tests if the Invisalign Palatal Expander can help kids and teens with certain dental issues grow their jaws better than traditional methods.

Quick facts

PhaseNA
Study typeInterventional
Enrollment120 (estimated)
Ages6 Years to 14 Years
SexAll
SponsorUniversity of the Pacific (other)
Locations1 site (San Francisco, California)
Trial IDNCT06414863 on ClinicalTrials.gov

What this trial studies

This study aims to assess the effectiveness of the Invisalign Palatal Expander system in growing patients by comparing its treatment outcomes to conventional methods. It employs a randomized controlled trial design to ensure robust results. The focus is on patients with specific dental conditions, particularly those requiring palatal expansion due to transverse maxillary deficiency. The study will include participants in the mixed dentition phase or early permanent dentition stage.

Who should consider this trial

Good fit: Ideal candidates for this study are children in the mixed dentition phase or early permanent dentition stage with specific dental issues like unilateral or bilateral posterior crossbites.

Not a fit: Patients with general medical health problems, craniofacial anomalies, or those with a skeletal Class III relationship may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a less invasive and more effective alternative for palatal expansion in children and adolescents.

How similar studies have performed: While there is limited information on the success of similar studies, the use of innovative orthodontic devices like the Invisalign system has shown promise in other contexts.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion criteria:

1. Mixed dentition phase with at least three nonmobile (stable) teeth which have more than 1/4 of primary molar root length left16 in either side
2. Early permanent dentition stage and early permanent dentition but second permanent molars not yet fully erupted in the arch
3. Unilateral or bilateral posterior cross bite patients; or Patients who have been diagnosed with transverse maxillary deficiency (Skeletal transverse discrepancy measured from the estimated center of resistances of the first molars17 ≤ - 3 mm);
4. Patients with Class I or Class II skeletal relationship
5. Subjects willing to consent to the trial

Exclusion Criteria:

1. Any general medical health problems which may influence treatment
2. Any craniofacial anomalies
3. Skeletal Class III patients
4. Mixed dentition patients with more than 2 heavily restored primary second or permanent first molars.

Where this trial is running

San Francisco, California

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Palatal Expansion Technique

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.