Evaluating the effectiveness of GentleWave technology in root canal treatment

Histological Evaluation in the Efficacy of GentleWave in Root Canal Pulp Tissue Debridement and Disinfection of Difficult to Reach Areas in Mandibular Human Molars II. An In-vivo Study.

Not applicable Interventional The University of Texas Health Science Center, Houston · NCT04105907

This study is testing if the GentleWave system can clean and disinfect hard-to-reach areas in molars to help patients who are considering tooth extraction.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment50 (estimated)
Ages18 Years to 70 Years
SexAll
SponsorThe University of Texas Health Science Center, Houston Academic / other
Locations1 site (Houston, Texas)
Trial IDNCT04105907 on ClinicalTrials.gov

What this trial studies

This study aims to assess the efficacy of the GentleWave system in debriding and disinfecting pulp tissue in difficult-to-reach areas of mandibular molars. It will involve in-vivo histological evaluations to gather evidence on the effectiveness of this innovative technology. The study focuses on teeth that patients have opted to extract rather than pursue other dental treatments, ensuring a specific patient population for analysis.

Who should consider this trial

Good fit: Ideal candidates for this study are patients who have chosen to extract their teeth instead of undergoing other dental treatments.

Not a fit: Patients with root fractures, previously treated root canals, or severe structural loss of teeth will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve root canal treatment outcomes and patient experiences by providing a more effective disinfection method.

How similar studies have performed: While the GentleWave technology is relatively novel, similar studies have shown promising results in improving root canal treatment efficacy.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Only teeth that patient decided to have the extraction done instead of having any other type of dental treatment and teeth extracted at patient's petition.

Exclusion Criteria:

* Teeth with root fractures or previously root canal treated teeth.
* Teeth with severe loss of structure
* Children

Where this trial is running

Houston, Texas

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Root Canal TreatmentGentleWaveMultisonicationSonendo
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.