Evaluating the effect of NSAIDs on pleurodesis quality after surgery for pneumothorax
Does Non-Steroidal Anti-inflammatory Drugs Decrease the Quality of Pleurodesis After Mechanical Pleural Abrasion/Pleurectomy for Treatment of Pneumothorax?
This study is testing if taking anti-inflammatory medications can help people who have had surgery for a collapsed lung recover better and reduce the chances of it happening again.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Enrollment | 116 (estimated) |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06467318 on ClinicalTrials.gov |
What this trial studies
This study investigates whether non-steroidal anti-inflammatory drugs (NSAIDs) can improve the quality of pleurodesis following mechanical pleural abrasion or pleurectomy in patients with primary or secondary spontaneous pneumothorax. The primary outcome is the recurrence of pneumothorax within six months, assessed through X-rays and symptom evaluation. Secondary outcomes include the length of hospital stay, time to chest tube removal, and opioid usage. The study aims to clarify the role of NSAIDs in managing inflammation and fibrosis during the healing process after pleurodesis.
Who should consider this trial
Good fit: Ideal candidates include individuals of all ages diagnosed with primary or secondary spontaneous pneumothorax who are undergoing pleurodesis.
Not a fit: Patients with contraindications to NSAIDs, such as those with bleeding tendencies, chronic kidney disease, or allergies to NSAIDs, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved outcomes and reduced recurrence rates for patients undergoing pleurodesis for pneumothorax.
How similar studies have performed: While the use of NSAIDs in various surgical contexts has been explored, this specific application in pleurodesis is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients presented with primary or secondary spontaneous pneumothorax * Age: All age groups are included * Approach: Open and Video assisted thoracoscopic surgery ( Open and VATS pleurodesis). Exclusion Criteria: * Refusal of procedure or participation in the study. * Patient with any contra indication for NSAID (bleeding tendency , CKD , gastritis , allergy to NSAID ,…..)
Where this trial is running
Cairo
- Faculty of medicine, Ain shams university — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Hany Hassan, Professor
- Email: hanyhassan77@hotmail.com
- Phone: +201227373270
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.