Clinical trial Recruiting at 1 site Observational Ages 18 and up

Evaluating the effect of dental screenings on infective endocarditis risk in heart valve surgery patients

Official title: Impact of Targeted Preoperative Dental Screening on Post-procedural Risk of Infective Endocarditis in Patients Undergoing Surgical Valve Replacement: a Prospective Observational Study

Run by Odense University Hospital · NCT06403839 · Data updated 2026-11-12

This study is testing whether changing dental screening procedures can lower the risk of infective endocarditis in patients having heart valve surgery.

More Dental Caries trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1000 (estimated)
SponsorOdense University Hospital
Academic / other
Locations1 site (Odense)
StatusRecruiting
StartedJanuary 1, 2020
Main results expectedMarch 1, 2027
Study endsMarch 1, 2028
Registry record updatedOctober 15, 2026
Trial IDNCT06403839 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients scheduled to undergo surgical valve replacement.

Probably not a fit

Patients who are not undergoing surgical valve replacement or those with urgent surgical needs may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study at Odense University Hospital examines the impact of changing preoperative dental screening protocols on the risk of infective endocarditis (IE) in patients undergoing surgical valve replacement. The study compares the incidence of IE before and after the implementation of a targeted dental screening approach starting in March 2024. Given the high risk of IE in patients with prosthetic left-sided valves, the study aims to provide insights into the effectiveness of dental screenings in reducing this risk. The findings will be based on registry data and will help inform future guidelines and practices.

Why it matters

Potential benefit: If successful, this study could lead to improved guidelines for dental screenings, potentially reducing the incidence of infective endocarditis in surgical valve replacement patients.

How similar studies have gone: Previous studies have shown no significant difference in IE risk between mandatory and no preoperative dental screening, making this investigation particularly relevant.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients undergoing surgical valve replacement

Exclusion Criteria:

* None

Where it's running

  • Odense University Hospital, Cardiac Surgery Department
    Odense, Denmark
    Recruiting

Study contacts

  • Principal investigator: Lytfi Krasniqi, MD — Denmark Odense University Hospital
  • Study coordinator: Lytfi Krasniqi, MD
  • Email: Lytfi.Krasniqi@rsyd.dk
  • Phone: 004524638899

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.