Evaluating the effect of dental screenings on infective endocarditis risk in heart valve surgery patients
Impact of Targeted Preoperative Dental Screening on Post-procedural Risk of Infective Endocarditis in Patients Undergoing Surgical Valve Replacement: a Prospective Observational Study
This study is testing whether changing dental screening procedures can lower the risk of infective endocarditis in patients having heart valve surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Odense University Hospital Academic / other |
| Locations | 1 site (Odense) |
| Trial ID | NCT06403839 on ClinicalTrials.gov |
What this trial studies
This observational study at Odense University Hospital examines the impact of changing preoperative dental screening protocols on the risk of infective endocarditis (IE) in patients undergoing surgical valve replacement. The study compares the incidence of IE before and after the implementation of a targeted dental screening approach starting in March 2024. Given the high risk of IE in patients with prosthetic left-sided valves, the study aims to provide insights into the effectiveness of dental screenings in reducing this risk. The findings will be based on registry data and will help inform future guidelines and practices.
Who should consider this trial
Good fit: Ideal candidates for this study are patients scheduled to undergo surgical valve replacement.
Not a fit: Patients who are not undergoing surgical valve replacement or those with urgent surgical needs may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved guidelines for dental screenings, potentially reducing the incidence of infective endocarditis in surgical valve replacement patients.
How similar studies have performed: Previous studies have shown no significant difference in IE risk between mandatory and no preoperative dental screening, making this investigation particularly relevant.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing surgical valve replacement Exclusion Criteria: * None
Where this trial is running
Odense
- Odense University Hospital, Cardiac Surgery Department — Odense, Denmark (Recruiting)
Study contacts
- Principal investigator: Lytfi Krasniqi, MD — Denmark Odense University Hospital
- Study coordinator: Lytfi Krasniqi, MD
- Email: Lytfi.Krasniqi@rsyd.dk
- Phone: 004524638899
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.