Evaluating the effect of dental screenings on infective endocarditis risk in heart valve surgery patients
Official title: Impact of Targeted Preoperative Dental Screening on Post-procedural Risk of Infective Endocarditis in Patients Undergoing Surgical Valve Replacement: a Prospective Observational Study
Run by Odense University Hospital · NCT06403839 · Data updated 2026-11-12
This study is testing whether changing dental screening procedures can lower the risk of infective endocarditis in patients having heart valve surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Odense University Hospital Academic / other |
| Locations | 1 site (Odense) |
| Status | Recruiting |
| Started | January 1, 2020 |
| Main results expected | March 1, 2027 |
| Study ends | March 1, 2028 |
| Registry record updated | October 15, 2026 |
| Trial ID | NCT06403839 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients scheduled to undergo surgical valve replacement.
✕Probably not a fit
Patients who are not undergoing surgical valve replacement or those with urgent surgical needs may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study at Odense University Hospital examines the impact of changing preoperative dental screening protocols on the risk of infective endocarditis (IE) in patients undergoing surgical valve replacement. The study compares the incidence of IE before and after the implementation of a targeted dental screening approach starting in March 2024. Given the high risk of IE in patients with prosthetic left-sided valves, the study aims to provide insights into the effectiveness of dental screenings in reducing this risk. The findings will be based on registry data and will help inform future guidelines and practices.
Why it matters
Potential benefit: If successful, this study could lead to improved guidelines for dental screenings, potentially reducing the incidence of infective endocarditis in surgical valve replacement patients.
How similar studies have gone: Previous studies have shown no significant difference in IE risk between mandatory and no preoperative dental screening, making this investigation particularly relevant.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing surgical valve replacement Exclusion Criteria: * None
Where it's running
-
Odense University Hospital, Cardiac Surgery Department
Odense, Denmark Recruiting
Study contacts
- Principal investigator: Lytfi Krasniqi, MD — Denmark Odense University Hospital
- Study coordinator: Lytfi Krasniqi, MD
- Email: Lytfi.Krasniqi@rsyd.dk
- Phone: 004524638899
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Evaluating the effect of dental screenings on endocarditis risk in TAVI patients
This study looks at whether changing dental check-up rules can lower the risk of heart infections in patients getting a new heart valve through a procedure called TAVI.
-
Insomnia and Post-Dental Surgery Pain: A Look at Sleep Quality and Pain After Tooth Extractions
This study tests whether preoperative sleep problems influence how much pain people feel after routine tooth extractions.
-
Barts Endocarditis Registry
This registry collects health, imaging, microbiology, treatment, and outcome information from adults with infective endocarditis seen at Barts Heart Centre to learn which approaches work best.
-
Parametric PET imaging for infections on prosthetic heart valves
This study will test whether an advanced parametric PET scan helps diagnose infections in people with prosthetic heart valves.
-
Comparing patients with and without endocarditis undergoing valve surgery
This study looks at how patients with and without endocarditis do during heart valve surgery to see if their treatment and recovery needs are different.
-
Cytokine removal in critically ill patients with infective endocarditis
This study is testing if a treatment that removes certain immune proteins can help critically ill patients with infective endocarditis recover better after heart surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.