Evaluating the best anesthetic for knee osteoarthritis injections
Optimal Anesthetic for Corticosteroid Injections for Knee Osteoarthritis.
PHASE1 · Foundation for Orthopaedic Research and Education · NCT05906433
This study is testing whether using different amounts of anesthetic during knee osteoarthritis injections can help reduce pain and improve comfort for patients.
Quick facts
| Phase | PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Foundation for Orthopaedic Research and Education (other) |
| Locations | 1 site (Tampa, Florida) |
| Trial ID | NCT05906433 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the effectiveness of corticosteroid injections for knee osteoarthritis by comparing pain relief with and without anesthetic, as well as varying volumes of anesthetic. Pain relief will be measured using the Visual Analog Scale (VAS) at the time of injection and at multiple follow-up points to determine the duration of relief. The study will also evaluate patient tolerance to the injections and hypothesizes that lower volumes of anesthetic will result in less pain during the procedure without significant differences in pain levels among the groups.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with primary osteoarthritis at Kellgren Lawrence Stage II or III.
Not a fit: Patients with inflammatory arthritis, those with a history of narcotic use in the past six months, or those at Kellgren Lawrence grade 1 or 4 will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients with knee osteoarthritis.
How similar studies have performed: Other studies have explored similar approaches to pain management in osteoarthritis, indicating potential for success, though this specific methodology is less commonly tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients must be 18 years of age and be able to consent for themselves. 2. OA grade Kellgren Lawrence Stage II or III. 3. Diagnosis of primary osteoarthritis. Exclusion Criteria: 1. Patients with other forms of arthritis such as inflammatory arthritis. 2. History of narcotic use for the past 6 months. 3. Kellgren Lawrence arthritis grade 1 or 4. 4. Pregnant women and prisoners.
Where this trial is running
Tampa, Florida
- Florida Orthopaedic Institute — Tampa, Florida, United States (RECRUITING)
Study contacts
- Study coordinator: Anne Meredith Baldy, CCRC
- Email: ambaldy@foreonline.org
- Phone: (813)978-9700
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Knee Osteoarthritis, knee injection, Knee osteoarthritis, corticosteroid