Clinical trial Recruiting at 1 site Observational Ages 18 and up Women only

Evaluating the Benefits of a Third MMRV Vaccine Dose for Adults in Alberta

Official title: Is a Third Dose of Measles-mumps-rubella-(Varicella) Vaccine (MMR(V)) Vaccine Beneficial for the Adult Population in Alberta?

Run by University of Alberta · NCT05923970 · Data updated 2026-11-12

This study is trying to see if giving a third dose of the MMRV vaccine can boost the immune response in women who didn't have strong enough protection after their first two doses.

More Vaccine Response Impaired trials

Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment200 (estimated)
SponsorUniversity of Alberta
Academic / other
Locations1 site (Edmonton, Alberta)
StatusRecruiting
StartedNovember 9, 2024
Main results expectedSeptember 30, 2027
Study endsSeptember 30, 2027
Registry record updatedMarch 16, 2026
Trial IDNCT05923970 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are pregnant women who have undergone routine prenatal screening for rubella antibodies.

Probably not a fit

Patients who are younger than 18 years of age will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates whether a third dose of the measles-mumps-rubella-varicella (MMRV) vaccine can enhance immune responses in women who have low antibody levels after receiving the standard two doses. It focuses on assessing both humoral and cell-mediated immune responses to determine the effectiveness of additional vaccination in preventing infections. The study will not administer the vaccine but will analyze serological data from participants to understand their immune status better. The findings aim to clarify the protection levels in highly vaccinated populations, particularly concerning prenatal health risks.

Why it matters

Potential benefit: If successful, this study could lead to improved vaccination strategies that enhance immunity in vulnerable populations, particularly pregnant women.

How similar studies have gone: While this approach is novel in assessing the need for a third dose in adults, similar studies have highlighted waning immunity in vaccinated populations, indicating a potential need for further investigation.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Women who are pregnant and have undergone routine prenatal screening for rubella antibodies.

Exclusion Criteria:

* Women younger than 18 years of age

Where it's running

  • University of Alberta
    Edmonton, Alberta, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.