Evaluating the Benefits of a Third MMRV Vaccine Dose for Adults in Alberta
Official title: Is a Third Dose of Measles-mumps-rubella-(Varicella) Vaccine (MMR(V)) Vaccine Beneficial for the Adult Population in Alberta?
Run by University of Alberta · NCT05923970 · Data updated 2026-11-12
This study is trying to see if giving a third dose of the MMRV vaccine can boost the immune response in women who didn't have strong enough protection after their first two doses.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 200 (estimated) |
| Sponsor | University of Alberta Academic / other |
| Locations | 1 site (Edmonton, Alberta) |
| Status | Recruiting |
| Started | November 9, 2024 |
| Main results expected | September 30, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | March 16, 2026 |
| Trial ID | NCT05923970 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are pregnant women who have undergone routine prenatal screening for rubella antibodies.
✕Probably not a fit
Patients who are younger than 18 years of age will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates whether a third dose of the measles-mumps-rubella-varicella (MMRV) vaccine can enhance immune responses in women who have low antibody levels after receiving the standard two doses. It focuses on assessing both humoral and cell-mediated immune responses to determine the effectiveness of additional vaccination in preventing infections. The study will not administer the vaccine but will analyze serological data from participants to understand their immune status better. The findings aim to clarify the protection levels in highly vaccinated populations, particularly concerning prenatal health risks.
Why it matters
Potential benefit: If successful, this study could lead to improved vaccination strategies that enhance immunity in vulnerable populations, particularly pregnant women.
How similar studies have gone: While this approach is novel in assessing the need for a third dose in adults, similar studies have highlighted waning immunity in vaccinated populations, indicating a potential need for further investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women who are pregnant and have undergone routine prenatal screening for rubella antibodies. Exclusion Criteria: * Women younger than 18 years of age
Where it's running
-
University of Alberta
Edmonton, Alberta, Canada Recruiting
Study contacts
- Study coordinator: Carmen Charlton, PhD
- Email: carmen.charlton@albertahealthservices.ca
- Phone: 1 (780) 407-8975
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.