Evaluating targeted therapy effectiveness in advanced lung cancer using RecistTM criteria

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the efficacy of the RecistTM criteria in evaluating targeted therapy for patients with advanced non-small cell lung cancer (NSCLC) who have positive driving genes. The study will analyze the correlation between tumor marker abnormalities and treatment outcomes, focusing on patients receiving first-line targeted therapy. Investigators will use statistical methods to compare the RecistTM criteria with traditional RECIST criteria and explore the relationship between treatment efficacy and circulating tumor DNA levels. The goal is to refine the evaluation rules of RecistTM to enhance its reliability in clinical settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* NSCLC patients with stage IIIB-IV
* Driver gene positive (EGFR,ALK,C-MET, ROS,RET, HER2);
* First line targeted therapy.
* Performance status of 0-2 on the ECOG criteria.
* Any one of the tumor markers is more than three times higher than the normal level, and the tumor markers include: CEA\>15ng/ml,CA-199\>105U/ml,CA-125\>105 U/ml, NSE\>60 ng/ml, SCCAg\>7.5 ng/ml, CYFRA21-1\>21 ng/ml, et al.
* Measurable lesions present
* Age\>=18
* Adequate hematologic (neutrophil count \>= 1,500/uL, platelets \>= 60,000/uL,hemoglobin≥70g/L), hepatic (transaminase =\< upper normal limit(UNL)x2.5, bilirubin level =\< UNLx1.5), and renal (creatinine =\< UNL) function.
* Informed consent from patient or patient's relative.

Exclusion Criteria:

* Patients with dysphagia;
* Unable to taking medication on time;
* Patients with a history of abuse of psychotropic substances who are unable to quit or have mental disorders

Where it's running

• Cancer Center, Dapping Hospital, Army Medical Center of PLA
  Chongqing, Chongqing Municipality, China Recruiting

Study contacts

• Study coordinator: Xueqin Yang, PhD
• Email: yangxueqin@hotmail.com
• Phone: 15923366936

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.