Evaluating synovitis in adults with haemophilia A
Prevalence of Synovitis in Adult Patients With Haemophilia A in Germany and Austria
This study looks at how often adults with hemophilia A experience joint inflammation caused by bleeding and how it affects their joint health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | Male |
| Sponsor | University Hospital, Bonn Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Bonn, North Rhine-Westphalia) |
| Trial ID | NCT06352216 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the prevalence of synovitis in adult patients diagnosed with haemophilia A. The research focuses on understanding how recurrent joint bleeding, a common complication of this bleeding disorder, leads to inflammation and subsequent joint damage. Utilizing ultrasound technology, the study will document the condition of the synovial tissue and its impact on joint health. Participants will be required to provide detailed medical histories, including bleeding events and treatment regimens, to ensure comprehensive data collection.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with moderate to severe haemophilia A.
Not a fit: Patients with other bleeding disorders or those currently participating in clinical studies involving investigational drugs may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of joint health in haemophilia A patients and inform better management strategies to prevent joint damage.
How similar studies have performed: While this study focuses on a specific aspect of haemophilia A, similar studies have shown the importance of monitoring joint health in patients with bleeding disorders, indicating a potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants (≥ 18 years old) suffering from moderate or severe haemophilia A, also with inhibitor or joint replacement * Complete documentation of hemophilia severity, treatment history (past 12 months), and bleeding events (past 12 months), inhibitor status (at time of enrollment and in past medical history) * Submitted written consent to participate in the study Exclusion Criteria: * Patients suffering from other bleeding disorders conflicting with the research question * Patients in clinical studies with investigational drugs
Where this trial is running
Bonn, North Rhine-Westphalia
- University Hospital Bonn — Bonn, North Rhine-Westphalia, Germany (Recruiting)
Study contacts
- Principal investigator: Andreas C Strauss, PD Dr. med. — University Hospital, Bonn
- Study coordinator: Andreas C. Strauss, PD Dr. med.
- Email: andreas.strauss@ukbonn.de
- Phone: +4922828714176
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.