Evaluating surgery for high-risk prostate cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the safety and early efficacy of radical prostatectomy in men diagnosed with very high-risk locally advanced and oligometastatic prostate cancer. The study aims to explore whether local tumor control through surgery can improve outcomes for patients who typically have a poor prognosis with standard treatments. Participants will undergo radical prostatectomy, and their outcomes will be monitored to assess the effectiveness of this approach compared to traditional therapies. The trial seeks to provide new insights into treatment options for advanced prostate cancer.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adenocarcinoma of the prostate
* Very high risk PCA (PSA ≥ 20 oder Gleason Score ≥ 8 oder ≥ cT3) and/or oligometastasierte PCA (T any N positive M any, oder T any N any M positive)
* ≤5 bone metastasis
* ≤75 years
* Ability for informed consent
* Clinically no infiltration into the rectum or pelvic wall
* Clinically no visceral metastasis
* Male, \>18 Jahre
* Fit for surgery
* ECOG Performance Status 0 oder 1

Exclusion Criteria:

* Male, \< 18 Jahre
* \> 5 bone metastasis
* \> 75 years
* No ability for informed consent
* Clinically infiltration into the rectum or pelvic wall
* Not fit for surgery
* Clinically visceral metastasis

Where it's running

• Medical University of Vienna
  Vienna, Austria Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.