Evaluating SKB500 for advanced solid tumors

A Phase I Clinical Study on the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of SKB500 for Injection in Subjects With Advanced Solid Tumors

This study is testing a new treatment called SKB500 to see if it is safe and effective for people with advanced solid tumors.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 180 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (Industry-sponsored)
• Drugs / interventions: chemotherapy, immunotherapy, radiation
• Locations: 1 site (Jilin)
• Trial ID: NCT06736327 on ClinicalTrials.gov

What this trial studies

This multicenter, open-label Phase I clinical trial aims to assess the safety, tolerability, pharmacokinetics, immunogenicity, and antitumor activity of SKB500 in patients with advanced solid tumors. The study consists of a dose-escalation phase, a dose-expansion phase, and an indication-expansion phase to determine the optimal dosing and effectiveness of the treatment. Participants will be closely monitored for any adverse effects and overall response to the therapy.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 to 75 with histologically confirmed advanced solid tumors that are resistant to standard therapies.

Not a fit: Patients with known active CNS metastases or those who have not recovered from prior treatment toxicities may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with advanced solid tumors that have limited or no effective standard treatments.

How similar studies have performed: While this approach is being explored in this specific context, similar studies have shown promise in evaluating new treatments for advanced solid tumors.

Eligibility criteria

Inclusion Criteria:

1. Male or female participants between 18 and 75 years old.
2. Histologically or cytologically confirmed advanced solid tumors for which standard treatment either does not exist or has proven ineffective or intolerable.
3. Subjects should ideally provide a tumor tissue sample for biomarker testing during the screening period.
4. Has at least 1 measurable lesion according to Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1
5. ECOG performance status score of 0 or 1.
6. Expected survival of at least 12 weeks.
7. Has adequate hematopoietic, renal and hepatic functions.
8. Have recovered to grade ≤ 1 of prior anti-cancer treatment toxicities.
9. Male and female subjects must agree to use highly effective contraceptive methods throughout the study.
10. Subjects must voluntarily enter the study, sign the informed consent form, and be able to comply with the visits and procedures.

Exclusion Criteria:

1. Subjects with known active CNS metastases, carcinomatous meningitis, leptomeningeal metastases, or spinal cord compression.
2. Subjects with other malignancies within 5 years before the first dose.
3. Any severe and/or uncontrolled concurrent disease that may interfere with the subject's participation in the study.
4. Active hepatitis B, or hepatitis C; active tuberculosis, or human immunodeficiency virus (HIV) test positive, or known acquired immunodeficiency syndrome (AIDS).
5. History of allergy to any component of SKB500 or history of severe hypersensitivity reactions to other monoclonal antibodies.
6. Subjects with a history of interstitial lung disease, non-infectious pneumonia, or other pulmonary diseases significantly affecting lung function.
7. History of allogeneic organ transplantation or hematopoietic stem cell transplantation.
8. Uncontrolled pleural effusion, ascites, or pericardial effusion.
9. Have received ADCs with the same target or the same toxins.
10. Have received chemotherapy, small molecule targeted therapy, and traditional Chinese medicine preparations within 14 days or 5 half-lives before the first dose; have received any immunotherapy, large molecule anticancer drug treatment, or more than 30% bone marrow radiation or extensive radiotherapy within 28 days before the first dose.
11. Have undergone major surgery or severe trauma within 28 days before the first dose.
12. Have received other clinical trial medications within 28 days before the first dose.
13. Has previously received anti-cancer or live vaccines within 28 days before the first dose
14. Have received systemic steroids or other immunosuppressive treatments within 14 days before the first dose.
15. Have received potent CYP3A4 inhibitors, inducers, or BCRP inhibitors within 14 days or 5 half-lives before the first dose.
16. Pregnant or lactating female.
17. Any disease or condition that, in the investigator's opinion, would compromise subject safety or interfere with study assessments.

Where this trial is running

Jilin

• JILIN Cancer Hospital — Jilin, China (Recruiting)

Study contacts

• Study coordinator: Yan Qing

Conditions Advanced Solid Tumors