Evaluating Serplulimab with Chemotherapy for Small-cell Lung Cancer from EGFR-mutated Non-small Cell Lung Cancer

Evaluation of Safety and Efficacy of Serplulimab Plus Chemotherapy in Patients With Histological Transformation From EGFR-mutated NSCLC to SCLC After Treatment: a Single-arm, Multicenter, Open-label Phase II Study

This study is testing if adding Serplulimab to chemotherapy can help people whose EGFR-mutated non-small cell lung cancer has changed into small-cell lung cancer and who haven't had treatment yet.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 66 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Guangdong Association of Clinical Trials (other)
• Drugs / interventions: immunotherapy, Serplulimab, chemotherapy
• Locations: 1 site (Guangzhou, Guangdong)
• Trial ID: NCT05957510 on ClinicalTrials.gov

What this trial studies

This Phase II clinical trial aims to assess the safety and efficacy of Serplulimab combined with chemotherapy in patients whose EGFR-mutated non-small cell lung cancer has transformed into small-cell lung cancer. The study will enroll participants who have not received systemic anticancer therapy after this transformation. Patients will be divided into three cohorts, with the first two cohorts receiving a specific chemotherapy regimen including Serplulimab, etoposide, and carboplatin, administered intravenously over several cycles. The trial is being conducted across multiple centers in China, focusing on a targeted patient population.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-75 with a confirmed diagnosis of EGFR-mutated non-small cell lung cancer that has transformed into small-cell lung cancer without prior systemic therapy post-transformation.

Not a fit: Patients who have received systemic therapy or immunotherapy after their cancer transformation may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with small-cell lung cancer that has transformed from EGFR-mutated non-small cell lung cancer.

How similar studies have performed: While this approach is novel in the context of transformed SCLC from EGFR-mutated NSCLC, similar studies have shown promise in evaluating combination therapies for lung cancer.

Eligibility criteria

Inclusion Criteria:

* Volunteer to participate in clinical studies.
* Age 18-75 (including the cut-off value) when signing the Informed Consent Form (ICF)
* Patients must provide pathological diagnosis reports and genetic testing reports before transformation, and the reports clearly indicate that they were non-small cell lung cancer containing EGFR mutations before transformation.
* Patients must provide a pathological diagnosis report after transformation, as well as 10 unstained reports after transformation. The pathology of the patients after transformation was SCLC or high-grade neuroendocrine carcinoma or containing SCLC components.
* Patients who have not received systemic therapy and anti-PD-1/L1 and CTLA-4 therapy after tissue type transformation. Patients are allowed to receive immunotherapy before transformation, but the last line of therapy cannot contain immunotherapy.
* The end of previous anti-tumor treatment must be more than 2 weeks from the first medication in this study, and the treatment-related AE should be recovered to CTCAE 5.0 ≤ grade 1 (except for grade 2 alopecia).
* At least one measurable target lesion based on Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) criteria identified within the four weeks leading up to the initial treatment dose
* ECOG PS 0 or 1
* Expected life expectancy of 12 weeks or more
* Adequate organ function
* The serum pregnancy test of female patients must be negative within 14 days before treatment, and effective contraceptive measures should be taken during treatment and within 6 months after treatment. Lactation is prohibited during treatment.
* Male patients must agree to abstinence (avoid heterosexual intercourse) or take contraceptive measures.

Exclusion Criteria:

* Patients cannot provide a pathology report after tissue type transformation.
* Patients with a known history of severe allergies to any monoclonal antibody ( NCI-CTCAE 5.0 grade greater than grade 3 ); or known hypersensitivity to carboplatin/etoposide components.
* Patients with known or screening findings of active central nervous system (CNS) metastases and/or cancerous meningitis (Exceptions will be made for patients with asymptomatic brain metastases or those who have had stable brain metastases for at least 4 weeks after treatment)
* Patients who have received systemic therapy or other immune checkpoint inhibitors after tissue type transformation; patients who are preparing for or have previously received organ or bone marrow transplantation.
* Any active infection requiring systemic anti-infectious therapy within 14 days before the first administration.
* Myocardial infarction or poorly controlled arrhythmia has occurred within 6 months before the first administration; or according to the NYHA standard III-IV cardiac insufficiency or echocardiography left ventricular ejection fraction \< 50 %; or pleural effusion, pericardial effusion or ascites requiring clinical intervention.
* Patients have uncontrolled or symptomatic hypercalcemia; Patients have poor blood pressure control; patients with deep vein thrombosis, being treated with anticoagulant or platelet therapy, or previous deep vein thrombosis or severe bleeding caused by the use of anti-angiogenic drugs; Patients with known active or suspected autoimmune diseases (Patients in a stable state who do not require systemic immunosuppressive therapy are allowed to be enrolled).
* Patients who have been and were screened and judged by the investigator to be likely to interfere with the detection and management of suspected drug-related lung toxicity; Patients who the investigator believes have any factors that are inappropriate for participating in this trial.
* Patients with hepatitis B; or hepatitis C patients; or syphilis screening positive; or known human immunodeficiency virus ( HIV ) positive history or HIV screening positive; known history of mental drug abuse or drug abuse.
* Other active malignancies tumors within 5 years or concurrently.
* Patients who were vaccinated with live or attenuated vaccines within 28 days before the first dose, or had plans to vaccinate such vaccines during the study period (but inactivated virus vaccines for seasonal influenza are allowed) or who underwent major surgery.
* Patients with spinal cord compression who have not been radically cured by surgery and/or radiotherapy. Received radical radiotherapy within 3 months before the first administration.
* Patients who were participating in other clinical studies, or who participated in any other clinical trials (including drugs and devices, etc.) and received intervention within 3 months or 5 half-lives (whichever is longer) before screening.

Where this trial is running

Guangzhou, Guangdong

• Guangdong Provincial Perople's Hospital — Guangzhou, Guangdong, China (RECRUITING)

Study contacts

• Principal investigator: Jin-Ji Yang, PhD — Guangdong Provincial People's Hospital
• Study coordinator: Jie Huang, PhD

Conditions: Small-cell Lung Cancer, transformed SCLC, EGFR-mutated NSCLC