Evaluating secretin levels in adolescents with anorexia nervosa
Official title: Secretin Levels in Refeeding-induced Polyuria (Cross Section)
Run by University of California, Los Angeles · NCT05235867 · Data updated 2026-11-12
This study is testing how secretin hormone levels differ in hospitalized teens with anorexia nervosa who have high urine output compared to those who don’t.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 13 Years to 24 Years |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | University of California, Los Angeles Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Status | Recruiting |
| Started | February 1, 2022 |
| Main results expected | June 30, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | February 12, 2026 |
| Trial ID | NCT05235867 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adolescents aged 13-24 diagnosed with restrictive-type anorexia nervosa who are hospitalized for nutritional support.
✕Probably not a fit
Patients with underlying metabolic disorders or those on certain medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on adolescents aged 13-24 with restrictive-type anorexia nervosa who are hospitalized for nutritional support. It aims to assess the differences in secretin hormone levels between patients who experience excessive urine output and those who do not. Participants will undergo an additional blood draw before and after a meal, along with providing a urine sample post-meal. The study will also utilize information from the patients' medical records to gather comprehensive data.
Why it matters
Potential benefit: If successful, this study could lead to improved management of anorexia nervosa by understanding the role of secretin in urine output and acid-base handling.
How similar studies have gone: While the specific approach of evaluating secretin in this context may be novel, similar studies have explored hormonal influences in anorexia nervosa with varying degrees of success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Group 1: * male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * \>4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5) * Group 2: * male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * \<2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5) Exclusion Criteria: * 5150 hold * Anti-depressant, anti-psychotic, or anticonvulsant medications * Previous hospitalization within the past 6 months * Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders) * Pregnancy * NG or G-tube feeds after day 2 of hospitalization * \> 10% of nutritional needs from supplemental feeds
Where it's running
-
University of California, Los Angeles (UCLA)
Los Angeles, California, United States Recruiting
Study contacts
- Study coordinator: Misciel Macaraig
- Email: mbmacaraig@mednet.ucla.edu
- Phone: 310-825-0922
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Comparing family-based telemedicine to inpatient treatment for anorexia nervosa
This study is testing if family-based treatment for anorexia nervosa delivered through telehealth is as effective as traditional inpatient care for teenagers with this condition.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.