Evaluating secretin levels in adolescents with anorexia nervosa
Secretin Levels in Refeeding-induced Polyuria (Cross Section)
This study is testing how secretin hormone levels differ in hospitalized teens with anorexia nervosa who have high urine output compared to those who don’t.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10 (estimated) |
| Ages | 13 Years to 24 Years |
| Sex | All |
| Sponsor | University of California, Los Angeles Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT05235867 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on adolescents aged 13-24 with restrictive-type anorexia nervosa who are hospitalized for nutritional support. It aims to assess the differences in secretin hormone levels between patients who experience excessive urine output and those who do not. Participants will undergo an additional blood draw before and after a meal, along with providing a urine sample post-meal. The study will also utilize information from the patients' medical records to gather comprehensive data.
Who should consider this trial
Good fit: Ideal candidates are adolescents aged 13-24 diagnosed with restrictive-type anorexia nervosa who are hospitalized for nutritional support.
Not a fit: Patients with underlying metabolic disorders or those on certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of anorexia nervosa by understanding the role of secretin in urine output and acid-base handling.
How similar studies have performed: While the specific approach of evaluating secretin in this context may be novel, similar studies have explored hormonal influences in anorexia nervosa with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Group 1: * male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * \>4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5) * Group 2: * male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * \<2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5) Exclusion Criteria: * 5150 hold * Anti-depressant, anti-psychotic, or anticonvulsant medications * Previous hospitalization within the past 6 months * Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders) * Pregnancy * NG or G-tube feeds after day 2 of hospitalization * \> 10% of nutritional needs from supplemental feeds
Where this trial is running
Los Angeles, California
- University of California, Los Angeles (UCLA) — Los Angeles, California, United States (Recruiting)
Study contacts
- Study coordinator: Misciel Macaraig
- Email: mbmacaraig@mednet.ucla.edu
- Phone: 310-825-0922
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.