Evaluating salivary gland function in Sjögren's syndrome using imaging
Functional Analysis and Antigen Presentation in Striated Ductal Cells of Salivary Glands and Correlation With Sialoscintigraphy in Patients and Animal Models of Sjogren's Syndrome
NA · National Taiwan University Hospital · NCT06536075
This study is testing a new imaging technique to see how well the salivary glands are working in people with Sjögren's syndrome, whether they have dry mouth symptoms or not.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 20 Years to 70 Years |
| Sex | All |
| Sponsor | National Taiwan University Hospital (other) |
| Locations | 1 site (Taipei) |
| Trial ID | NCT06536075 on ClinicalTrials.gov |
What this trial studies
This study investigates the functional status of striated ductal cells in patients with Sjögren's syndrome through a non-invasive imaging technique called sialoscintigraphy. The researchers hypothesize that the sodium iodide symporter (NIS), which is predominantly expressed in these cells, can be assessed using technetium-99m radiotracer to evaluate gland function. By correlating NIS expression levels with clinical manifestations, the study aims to enhance understanding of the disease's mechanisms and improve diagnostic methods. The study will include patients with and without sicca symptoms who are already receiving sialoscintigraphy.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with Sjögren's syndrome, particularly those undergoing sialoscintigraphy.
Not a fit: Patients who are pregnant, breastfeeding, or have active cancer treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic tools for Sjögren's syndrome, allowing for better management of the condition.
How similar studies have performed: While the approach of using sialoscintigraphy in this context is novel, similar imaging techniques have shown promise in other autoimmune conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Nomogram: no sicca symptoms * Sicca: already receiving sialoscintigraphy Exclusion Criteria (generally): * pregnancy * breast feeding * HIV * cancer with active treatment (for nomogram) * chronic illness needed regular follow-up * Use anti-histamine, diuretics, anti-depressants, psychotropic medications, anxiolytics or NSAIDs that interfering saliva secretion * smoking in recent one year * Positive profiles for anti-SSA or anti-ENA
Where this trial is running
Taipei
- National Taiwan University Hospital — Taipei, Taiwan (RECRUITING)
Study contacts
- Principal investigator: National Taiwan University Hospital — National Taiwan University Hospital
- Study coordinator: CHIAO-FENG CHENG, MD
- Email: 103622@ntuh.gov.tw
- Phone: 0972652625
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Sjogren's Syndrome