Evaluating RJ4287 for safety and tolerability in healthy volunteers

A Phase 1, Double-blind, Randomized, Placebo-controlled, First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Food-effect of Single and Multiple Oral Doses of RJ4287 in Healthy Volunteers

This study is testing a new drug called RJ4287 to see if it's safe and how it works in healthy people when taken alone or with food.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 98 (estimated)
• Ages: 18 Years to 55 Years
• Sex: All
• Sponsor: Nanjing Ruijie Pharma Co., Ltd. (Industry-sponsored)
• Locations: 1 site (Bengbu, Anhui)
• Trial ID: NCT05921006 on ClinicalTrials.gov

What this trial studies

This study evaluates the safety, tolerability, and pharmacokinetics of RJ4287 through both single and multiple doses administered to healthy volunteers. Participants will be randomly assigned to receive either the drug or a placebo. The study aims to assess how the drug behaves in the body and its effects when taken with food. It is designed to gather important data that will inform future research and development of RJ4287.

Who should consider this trial

Good fit: Ideal candidates are healthy males and females aged 18 to 55 with specific weight and BMI criteria.

Not a fit: Patients with a history of thyroid disorders or significant abdominal ultrasound findings may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to a better understanding of RJ4287's safety profile, paving the way for its use in treating various conditions.

How similar studies have performed: Other studies evaluating similar drug safety and pharmacokinetics have shown success, indicating that this approach is well-established.

Eligibility criteria

Inclusion Criteria:

* Male and Female between 18 and 55 years old，inclusive
* Body weight \>50 kg for Male and \>45 kg for Female with a body mass index BMI between 19-28 kg/m2（inclusive）
* Female subjects of childbearing potential who have had no unprotected sex within 14 days prior to screening and who have had a negative pregnancy test during the screening period; subjects (including partners) who have no plans for pregnancy, sperm donation or egg donation and are willing to use effective contraception from the time of informed consent until 6 months after administration of the test product;
* The subject must be willing and able to provide written informed consent

Exclusion Criteria:

* History of thyroid disorder or abnormal thyroid function tests at screening
* Abnormal abdominal ultrasound findings with clinical significance
* Subjects with any of the following laboratory tests at screening or baseline were not eligible for enrollment in this study: 1) Glutamic transaminase (AST), glutamic aminotransferase (ALT) or direct bilirubin above the upper limit of the reference range at screening; 2) Positive screening for HIV antibodies, hepatitis B surface antigen, hepatitis C antibodies, syphilis antibodies ECG QTc \> 450 ms, QRS \> 110 ms, intermittent bundle branch block, frequent premature atrial or ventricular contractions at the time of screening, or any person who is considered clinically significant by the investigator; 4) A routine blood test with a white blood cell count, neutrophil count and lymphocyte count outside the normal reference range at screening and judged clinically significant by the investigator; 5) A kidney disease diet adjustment ( MDRD) formula calculated with an estimated glomerular filtration rate (eGFR) \< 90 mL
* Sensitivity to thyroid medication or history of sensitivity to a similar study drug(eg.MGL-3196)
* History of sensitivity to a similar study drug
* Major surgical procedure, previous gastrointestinal surgery, vagotomy, bowel resection or any surgical procedure that may interfere with peristalsis, pH or absorption in the gastrointestinal tract within 6 months prior to screening
* Subjects who, in the judgement of the investigator, have a condition that affects the absorption, distribution, metabolism and excretion of the drug (e.g. gastrointestinal dysfunction, peptic ulcer, gastrointestinal surgery, etc.) or who are unable to comply with a uniform diet during the trial
* Taken any prescription medication, over-the-counter medication, any vitamin product or herbal remedy within 1 month prior to screening
* Subjects with any current or previous illness that, in the opinion of the Investigator, might confound the results of the study or pose an additional risk in administering study drug to the subject or that could prevent, limit, or confound the protocol specified assessments or study results interpretation
* History of regular use nicotine or alcohol，unable to abstain from smoking and alcohol during the trial
* Previous blood donation or blood loss of more than 400 mL within 3 months prior to taking the study drug
* Had consumed a special diet (including popcorn, dragon fruit, mango, grapefruit, orange, etc.) or alcohol within 2 weeks before taking the study drug, or had strenuous exercise
* Taken an experimental drug or other experimental treatment within 3 months prior to screening, or being involved in any other interventional clinical trial
* Nursing female subjects
* Any other condition that, in the opinion of the investigator or sponsor, makes the subject unsuitable for inclusion in the study

Where this trial is running

Bengbu, Anhui

• The First Affiliated Hospital of Bengbu Medical College — Bengbu, Anhui, China (Recruiting)

Study contacts

• Study coordinator: Zhenning Li, MD

Conditions Drug Safety