Evaluating Right Ventricular Function in Heart Failure Patients
Valutazione Ecocardiografica Della Riserva Contrattile Del Ventricolo Destro Dopo Carico Volemico Acuto Mediante Sollevamento Passivo Delle Gambe e Durante Infusione di Dobutamina in Pazienti Affetti da Scompenso Cardiaco a Frazione d'Eiezione Ridotta (HFrEF) e Preservata (HFpEF)
NA · Istituto Auxologico Italiano · NCT05797584
This study tests how the right side of the heart works under stress in heart failure patients to see if it can help doctors better understand and treat their condition.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Sex | All |
| Sponsor | Istituto Auxologico Italiano (other) |
| Locations | 1 site (Milan, MI) |
| Trial ID | NCT05797584 on ClinicalTrials.gov |
What this trial studies
This study investigates the contractile reserve of the right ventricle in patients with heart failure, specifically those with reduced and preserved left ventricular ejection fraction. It aims to determine how the right ventricle responds to stress tests, such as passive leg raising and dobutamine infusion, which may reveal hidden dysfunction or normal function under stress. By comparing responses between two groups of patients, the study seeks to enhance prognostic stratification for heart failure patients. The findings could lead to better management strategies based on individual patient responses.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with heart failure, either with reduced or preserved left ventricular ejection fraction.
Not a fit: Patients with recent myocardial infarction, unstable angina, or significant valve disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the prognostic assessment and treatment strategies for heart failure patients.
How similar studies have performed: Preliminary evidence suggests that similar approaches have shown promise in assessing right ventricular function, but this specific methodology is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * heart failure with reduced (EF ≤40%) or preserved (EF \> 50%) ejection fraction * echocardiographic acoustic window adequate for evaluation of outcome parameters * presence of tricuspid insufficiency which allows assessment of pulmonary artery systolic pressure Exclusion Criteria: * recent myocardial infraction (\<3 months) or unstable angina * moderate o severe aortic or mitralic valve disease * inadequate acoustic window * significant anemia (hemoglobin \<10 g/dl) * recent heart surgery (\< 3 months).
Where this trial is running
Milan, MI
- Ospedale San Luca IRCCS Istituto Auxologico Italiano — Milan, MI, Italy (RECRUITING)
Study contacts
- Study coordinator: Sergio Caravita, MD, PhD
- Email: s.caravita@auxologico.it
- Phone: +390261911
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Heart Failure